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Table 3 Co-variates for a new cardiovascular event during five years after RA-onset in 442 patients.

From: Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study

Co-variates

HR

CI 95%

P-value

Sex f/m

0.314/f

0.177, 0.557

0.001

Age at onset of RA

1.060/yr

1.035, 1.086

<0.001

Diabetes mellitus

2.893/+

1.297, 6.452

<0.01

Hypertension, treated

4.066/+

2.308, 7.162

<0.001

BP, syst

1.015/mmHg

1.003, 1.026

<0.05

BP, diast

1.033/mmHg

1.003, 1.063

<0.05

S-HDL-chol

0.318/mmolL-1

0.090, 1.123

= 0.075

S-Triglycerides

1.919/mmolL-1

1.461, 2.521

<0.001

Statin treatment

2.237/+

0.950, 5.270

= 0.065

Previous CVE

5.912/+

3.210, 10.891

<0.001

AUC DAS28 (6 mo)

1.063

1.021, 1.106

<0.01

AUC DAS281

1.025

1.010, 1.040

<0.01

Extra-articular disease1

3.343/+

1.421, 7.867

<0.01

Corticosteroids at/before inclusion

1.030/mo

1.004, 1.056

<0.05

Corticosteroids1

2.243/+

1.208, 4.164

<0.05

DMARDs within 3 mo2

0.402/+

0.200, 0.808

<0.05

DMARDs1

0.885/mo

0.200, 0.808

<0.001

COX-2-inhibitors1

2.392/+

1.206, 4.744

<0.05

  1. Results of Simple Cox proportional hazards regression models, with fixed and time-dependent co-variates.
  2. 1 = Time-dependent co-variate
  3. 2DMARD treatment started within three months from baseline (T0).
  4. AUC, area under the curve; BP, blood pressure; CI, confidence interval; COX-2, cyclo-oxygenase-2; CVE, cardiovascular event; DAS28, disease activity score; DMARD, disease-modifying anti-rheumatic drug; HDL, high-density lipoprotein; HR, hazard ratio; RA, rheumatoid arthritis