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Table 3 Co-variates for a new cardiovascular event during five years after RA-onset in 442 patients.

From: Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study

Co-variates HR CI 95% P-value
Sex f/m 0.314/f 0.177, 0.557 0.001
Age at onset of RA 1.060/yr 1.035, 1.086 <0.001
Diabetes mellitus 2.893/+ 1.297, 6.452 <0.01
Hypertension, treated 4.066/+ 2.308, 7.162 <0.001
BP, syst 1.015/mmHg 1.003, 1.026 <0.05
BP, diast 1.033/mmHg 1.003, 1.063 <0.05
S-HDL-chol 0.318/mmolL-1 0.090, 1.123 = 0.075
S-Triglycerides 1.919/mmolL-1 1.461, 2.521 <0.001
Statin treatment 2.237/+ 0.950, 5.270 = 0.065
Previous CVE 5.912/+ 3.210, 10.891 <0.001
AUC DAS28 (6 mo) 1.063 1.021, 1.106 <0.01
AUC DAS281 1.025 1.010, 1.040 <0.01
Extra-articular disease1 3.343/+ 1.421, 7.867 <0.01
Corticosteroids at/before inclusion 1.030/mo 1.004, 1.056 <0.05
Corticosteroids1 2.243/+ 1.208, 4.164 <0.05
DMARDs within 3 mo2 0.402/+ 0.200, 0.808 <0.05
DMARDs1 0.885/mo 0.200, 0.808 <0.001
COX-2-inhibitors1 2.392/+ 1.206, 4.744 <0.05
  1. Results of Simple Cox proportional hazards regression models, with fixed and time-dependent co-variates.
  2. 1 = Time-dependent co-variate
  3. 2DMARD treatment started within three months from baseline (T0).
  4. AUC, area under the curve; BP, blood pressure; CI, confidence interval; COX-2, cyclo-oxygenase-2; CVE, cardiovascular event; DAS28, disease activity score; DMARD, disease-modifying anti-rheumatic drug; HDL, high-density lipoprotein; HR, hazard ratio; RA, rheumatoid arthritis