Table 1 The major functional groups represented by 322 differentially expressed genes at the incubation phase of adjuvant arthritis in Lewis ratsa
Functional group | Number (%) |
|---|---|
Innate immunity | 19 (5.9%) |
   Cell markers, innate immune response, complement |  |
Cell-mediated adaptive immune response and effector functions | 23 (7.1%) |
Stress protein-related and other autoantigens, antigen processing and presentation, T cell costimulation, cytokines and cytokine receptors, activators and regulators | Â |
Humoral immunity | 8 (2.5%) |
Cell proliferation | 113 (35.1%) |
DNA synthesis, replication, repair, tRNA processing, transcription, translation, cell cycle and cellular components | Â |
Cell migration | 24 (7.4%) |
   Adhesion molecules, integrins, chemokines and receptors, cell migration-related |  |
Angiogenesis | 2 (0.6%) |
Oxygen metabolism related to pathogenesis of arthritis | 11 (3.4%) |
   Transporters of oxygen, electrons, reactive oxygen species, cellular response to oxygen level and oxidation reduction |  |
Articular damage | 4 (1.2%) |
Metabolism | 25 (7.7%) |
   Glucose metabolism, proteolysis, peptide or amino acid transporter and protein metabolism, lipid metabolism and other metabolic processes |  |
Signal transduction and signaling pathways | 16 (5.0%) |
Phosphorylation and dephosphorylation, kinase activity and regulation, signal transduction and regulation, G protein-coupled receptor signaling pathway and others | Â |
Tumor- and disease-related | 8 (2.5%) |
Neuron development, neurotransmitters and neuropeptide signaling | 4 (1.2%) |
Ion binding and transporters, binding activity | 7 (2.1%) |
Undefined function and unnamed genes | 59 (18.3%) |