Effect of ONO-8815Ly in the late stages of degeneration (femur). Histological findings of (a) medial and (b) lateral femoral condyles at 12 weeks after the operation. Sections were prepared from samples of (a and f) G-S, (b and g) G-C, (c and h) G-0, (d and i) G-80, and (e and j) G-400, and stained with (a to e) H&E or (f to j) safranin-O. Magnification, 200× (H&E) and 40× (safranin-O). Scale bar, 200 μm (H&E) and 2.0 mm (safranin-O). Grade of degeneration scored using Mankin's system in (c) medial and (d) lateral femoral condyles at 12 weeks after the operation. Values are the mean ± standard deviation. N.S, not significant.