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Table 1 Statistical analysis of hRasGRP4 isoforms in healthy subjects and patients with RA and autoimmune controls

From: Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis

  normal variant (%) OR 95% CI P-value
Any variant      
Healthy subjects 62 18 (22.5)    
RA patients (total) 47 74 (67.3) 5.42 2.86 to 10.3 0.00000016
RA patients (untreated) 9 16 (64.0) 6.12 2.32 to 16.2 0.00029
Autoimmune controls 69 31 (31.0) 1.55 0.79 to 3.04 0.27
  non-variant 6 variant 6 OR 95% C.I. P- value
Variant 6      
Healthy subjects 79 1 (1.3)    
RA patients 95 20 (18.0) 16.6 2.18 to 126 0.00035
Autoimmune controls 92 8 (8.0) 6.87 0.84 to 56.1 0.038
  1. CI, confidential interval and P-values were calculated by Chi-square test to evaluate the incidence of alternative splicing with healthy subjects and patients groups. The frequency of variant 6 in each group was evaluated by Fisher's exact probability test. The percentage (%) of sequenced clones that contained an aberrant hRasGRP4 transcript is also indicated. OR, odds ratio; RA, rheumatoid arthritis