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Table 4 Comparison of effectiveness algorithm versus effectiveness gold standard for biologic and nonbiologic disease-modifying agent in rheumatic disease** treatments

From: Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis

  Effectiveness gold standard***    
Met effectiveness algorithm* Yes No Total PPV (95% CI) NPV (95% CI)
Yes 60 19 79 (26%) 76% (71 to 81)  
No 23 203 226 (74%)   90% (88 to 92)
Total 83 (27%) 222 (73%) 305 (100%)   
  Se = 72%
(95% CI = 67 to 77)
Sp = 91%
(95% CI = 89 to 93)
   
  1. CI: confidence Interval; DMARD: disease-modifying; NPV: negative predictive value; PPV: positive predictive value; Se: sensitivity; Sp: specificity. *The components of the effectiveness algorithm are given in Table 1. **DMARDs include hydroxychloroquine, leflunomide and sulfasalazine. ***Defined as DAS28 ≤ 3.2 or DAS28 improvement by > 1.2 units and high adherence (for example, ≥ 80%) to the biologic and/or DMARD started on the index date.