Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis

Table 4 Comparison of effectiveness algorithm versus effectiveness gold standard for biologic and nonbiologic disease-modifying agent in rheumatic disease** treatments

	Effectiveness gold standard***
Met effectiveness algorithm*	Yes	No	Total	PPV (95% CI)	NPV (95% CI)
Yes	60	19	79 (26%)	76% (71 to 81)
No	23	203	226 (74%)		90% (88 to 92)
Total	83 (27%)	222 (73%)	305 (100%)
	Se = 72% (95% CI = 67 to 77)	Sp = 91% (95% CI = 89 to 93)

CI: confidence Interval; DMARD: disease-modifying; NPV: negative predictive value; PPV: positive predictive value; Se: sensitivity; Sp: specificity. *The components of the effectiveness algorithm are given in Table 1. **DMARDs include hydroxychloroquine, leflunomide and sulfasalazine. ***Defined as DAS28 ≤ 3.2 or DAS28 improvement by > 1.2 units and high adherence (for example, ≥ 80%) to the biologic and/or DMARD started on the index date.

ISSN: 1478-6362