Increased IL-21 expression in T-cells of SLE patients. This figure shows a representative dot plot of cytokine expression in unstimulated (A) and stimulated (B) blood samples. Due to the down-regulation of CD4 after stimulation with PMA/Ca-Io cells were gated for CD3+CD8+ and CD3+CD8- T-cell subsets. Unstimulated samples were used as negative controls. The expression of IL-17A and IL-21 is shown for a healthy control and an SLE patient.