HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients

Table 1 Demographic, laboratory and clinical data for the RA patient group (n = 143)

Parameters	Data	Median [IQR]	Range
Age (years)	48 ± 12	48 [41 to 56]	20 to 75
Females, n (%)	118 (82.5%)
Blacks, n (%)	124 (86.7%)
DAS28-CRP	5.6 ± 1.3	5.7 [4.8 to 6.7]	2.3 to 8.7
Disease duration (months)	12 ± 7	10 [6 to 18]	0 to 25
Larsen radiographic scores	23 ± 14	19 [14 to 28]	1 to 66
RF (IU/ml)	490 ± 795	168 [38 to 595]	4 to 5,350
aCCP (U/ml)	669 ± 636	492 [85 to 1,099]	2 to 2,527
CRP (μg/L)	24 ± 32	14 [5 to 32]	0 to 198
SAA (μg/ml)	62 ± 123	14 [5 to 65]	1 to 882

aCCP = anticyclic citrullinated peptide antibodies; CRP = C-reactive protein; DAS28 = Disease Activity Score in 28 joints; RF = rheumatoid factor; SAA = serum amyloid A. Data are means ± SD, n (%), medians [25th to 75th IQR] or raw data as indicated.

ISSN: 1478-6362