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Table 2 Shared epitope classification according to amino acid sequence at positions 70-74

From: HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients

Allele classification Amino acid sequence positions 70 to 74 HLA-DRB1 alleles
S1 D-E-RAA *01:03, *04:02, *11:02-:03, *13:01-:02, *13:04, *13:36, *13:40
  Q-A-RAA *15
S2 Q-K-RAA *04:01, *04:09, *04:13, *04:35, *04:66
  D-K-RAA *13:03
S3D D-R-RAA *11:01, *11:04, *11:27, *12, *13:05-:06, *13:25, *14:22, *16
S3P Q-R-RAA *01:01-:02, *04:04-:05, *04:08, *04:10
  R-R-RAA *10:01
X Q-K-RGR *03
  Q-R-RAE *04:03, *04:07, *04:11
  D-R-RGQ *07
  D-R-RAL *08
  R-R-RAE *09:01, *14:01, *14:04
  1. HLA = human leucocyte antigen. Data in right column from Gao et al. [6].