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Table 2 Shared epitope classification according to amino acid sequence at positions 70-74

From: HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients

Allele classification

Amino acid sequence positions 70 to 74

HLA-DRB1 alleles

S1

D-E-RAA

*01:03, *04:02, *11:02-:03, *13:01-:02, *13:04, *13:36, *13:40

 

Q-A-RAA

*15

S2

Q-K-RAA

*04:01, *04:09, *04:13, *04:35, *04:66

 

D-K-RAA

*13:03

S3D

D-R-RAA

*11:01, *11:04, *11:27, *12, *13:05-:06, *13:25, *14:22, *16

S3P

Q-R-RAA

*01:01-:02, *04:04-:05, *04:08, *04:10

 

R-R-RAA

*10:01

X

Q-K-RGR

*03

 

Q-R-RAE

*04:03, *04:07, *04:11

 

D-R-RGQ

*07

 

D-R-RAL

*08

 

R-R-RAE

*09:01, *14:01, *14:04

  1. HLA = human leucocyte antigen. Data in right column from Gao et al. [6].