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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice

Figure 6

The cross-reactivity of purified anti-pp65 336-439 or anti-pp65 1-167 antibody to dsDNA. (a) ELISA assays for affinity-purified anti-pp65336-439 antibody (pp65336-439), anti-pp651-167 antibody (pp651-167), flow through and SLE patients' sera (SLE) against dsDNA. Graphs depict mean ± s.e.m. values. Unpaired Student t test was performed. Results with a P-value of < 0.05 were considered to be significant. (b) Representations of Crithidia luciliae stain by affinity-purified anti-pp65336-439 antibody (b 1 , pp65336-439), anti-pp651-167 antibody (b 2 , pp651-167), flow through (b 3 ) and SLE patients' sera (b 4 , SLE) against dsDNA. White arrowheads indicate the positive stains. (c) Representations of Immunofluorescent stain for immunoglobulin deposition on glomerular by pp65336-439 (c 1 ) immunized mice, pp651-167 (c 2 ) immunized mice, SA-C3d (c 3 ) immunized mice or PBS (c 4 ) controls. Kidneys were collected at 20 weeks of age. White arrowheads indicate antibody deposition on glomerular. dsDNA: double-stranded DNA.

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