CD161+ CD4+ T cells are increased in SSc and correlated with the percentage of IL-17A+CD4+ T cells. A, CD4+CD161+ T cells in the peripheral blood of SSc individuals (n = 21) and HD (n = 17) were identified by two-color flow-cytometry analysis. Bars show the means. B, Correlation between the percentage of IL-17A+CD4+ T cells and CD161+CD4+ T cells analyzed ex vivo. For cytokine intracellular localization, the conditions were as described in the legend of Figure 2. A two-tailed unpaired t-test (A) and Pearson correlation (B) were used for statistical analysis.