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Table 2 Multivariable Cox proportional hazards model for time to initiation of minocycline or doxycycline

From: Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects

  Hazard ratio 95% confidence interval Standard error P value
Male sex 1.139 0.887, 1.464 0.146 0.308
Age 0.990 0.982, 0.998 0.004 0.021
Number of previous nonbiologic DMARDs 1.618 1.532, 1.710 0.045 < 0.001
Methotrexate use 0.728 0.596, 0.890 0.074 0.002
Leflunomide use 0.622 0.470, 0.822 0.089 0.001
Azathioprine use 0.378 0.186, 0.769 0.137 0.007
Patient Activity Score 1.049 1.000, 1.100 0.026 0.051
Comorbidity index 1.139 1.072, 1.210 0.035 < 0.001
Number of previous biologic DMARDs 0.779 0.676, 0.898 0.057 0.001
Calendar year 1.062 1.001, 1.127 0.032 0.046
  1. n = 11,987. DMARD, disease-modifying anti-rheumatic drug.