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Table 3 Most common rheumatoid arthritis patient-reported side effects to minocycline and doxycycline and their severity

From: Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects

Side effect Mild Moderate Severe Total (%)
Minocycline     
   Skin, other 7 16 11 34 (25)
   Photosensitivity 2 9 4 15 (11)
   Purpura 2 10 1 13 (10)
   Dizziness 8 2 3 13 (10)
   Rash 0 3 5 8 (6)
   Nausea 1 2 4 7 (5)
   Headache 1 1 3 5 (4)
   Tinnitus 3 1 0 4 (3)
   Diarrhea 2 1 1 4 (3)
   Itching 0 2 1 3 (2)
   Gastrointestinal, other 0 2 1 3 (2)
   Abdominal pain 1 1 1 3 (2)
   Other 11 8 6 25 (18)
   Total (%) 38 (28) 58 (42) 41 (30) 137 (100)
Doxycycline     
   Nausea 3 10 4 17 (16)
   Skin, other 7 2 2 11 (10)
   Photosensitivity 2 4 3 9 (8)
   Dizziness 6 2 1 9 (8)
   Rash 0 5 3 8 (7)
   Abdominal pain 0 5 2 7 (6)
   Purpura 2 4 0 6 (6)
   Diarrhea 2 2 2 6 (6)
   Itching 0 3 0 3 (3)
   Tinnitus 2 1 0 3 (3)
   Heartburn 0 2 1 3 (3)
   Infections 0 1 2 3 (3)
   Other 7 12 6 25 (23)
   Total (%) 31 (28) 53 (48) 26 (24) 110 (100)