Table 3 Most common rheumatoid arthritis patient-reported side effects to minocycline and doxycycline and their severity

Minocycline

   Skin, other

7

16

11

34 (25)

   Photosensitivity

2

9

4

15 (11)

   Purpura

2

10

1

13 (10)

   Dizziness

8

2

3

13 (10)

   Rash

0

3

5

8 (6)

   Nausea

1

2

4

7 (5)

   Headache

1

1

3

5 (4)

   Tinnitus

3

1

0

4 (3)

   Diarrhea

2

1

1

4 (3)

   Itching

0

2

1

3 (2)

   Gastrointestinal, other

0

2

1

3 (2)

   Abdominal pain

1

1

1

3 (2)

   Other

11

8

6

25 (18)

   Total (%)

38 (28)

58 (42)

41 (30)

137 (100)

Doxycycline

   Nausea

3

10

4

17 (16)

   Skin, other

7

2

2

11 (10)

   Photosensitivity

2

4

3

9 (8)

   Dizziness

6

2

1

9 (8)

   Rash

0

5

3

8 (7)

   Abdominal pain

0

5

2

7 (6)

   Purpura

2

4

0

6 (6)

   Diarrhea

2

2

2

6 (6)

   Itching

0

3

0

3 (3)

   Tinnitus

2

1

0

3 (3)

   Heartburn

0

2

1

3 (3)

   Infections

0

1

2

3 (3)

   Other

7

12

6

25 (23)

   Total (%)

31 (28)

53 (48)

26 (24)

110 (100)