Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features

Table 3 Coincidence* of autoantibodies in 863 individual systemic sclerosis patients

Antibodies	ACA	ATA	Anti-PM-Scl	Anti-U1-RNP	Anti-RNAP	Anti-fibrilla-rin	Anti-To	Anti-Ku	Anti-Jo-1/Pl-7/OJ	Anti-U11-RNP	Anti-Ro52	Anti-Ro60	Anti-La	AMA	Anti-p25/p23	Anti-NOR-90	Anti-SL	Anti-Sm	Anti-Sp100	Other
ACA		1	0	1	0	0	0	0	0	0	92	11	1	31	28	4	2	0	3	144
ATA			1	2	0	0	0	4	0	0	36	26	6	4	0	1	4	1	0	77
Anti-PM-Scl				0	0	0	0	1	0	0	6	2	0	0	0	0	0	0	0	4
Anti-U1-RNP					1	0	0	0	0	0	11	6	1	2	0	1	0	4	0	11
Anti-RNAP						0	0	0	0	0	5	1	1	1	0	0	1	0	0	5
Anti-fibrillarin							0	0	0	0	0	0	0	1	0	0	0	0	0	8
Anti-To								0	0	0	1	1	0	0	0	0	0	0	0	2
Anti-Ku									0	0	2	2	0	0	0	0	1	0	0	2
Anti-Jo-1/Pl-7/OJ										0	3	0	0	0	0	0	0	0	0	1
Anti-U11-RNP											0	0	0	0	0	0	0	0	0	0
Anti-Ro52												41	15	14	11	2	5	2	2	97
Anti-Ro60													14	6	0	0	0	1	1	33
Anti-La														1	0	0	0	1	0	8
AMA															2	0	1	1	2	29
Anti-p25/p23																1	1	0	1	18
Anti-NOR-90																	0	1	0	4
Anti-SL																		0	0	3
Anti-Sm																			0	0
Anti-Sp100																				2
Other
Isolated^a	104	153	31	19	23	4	0	4	1	1	2	1	0	0	0	0	1	0	0	79
Total^b	310	260	42	41	33	12	2	10	4	1	187	59	16	41	28	6	9	4	4	363

*Number of patients with co-occurrences of autoantibodies. ^aIsolated: presence without coincidence of any other autoantibody by all detection methods used. ^bTotal number of individuals with the respective autoantibody; these numbers mostly are smaller than the sum of all co-occurrences plus the 'isolated' individuals listed because of some triple, quadruple and higher-order coincidences. ACA = anti-centromere antibodies; AMA = antimitochondrial antibodies; ATA = anti-topoisomerase I antibodies;; RNAP = RNA polymerase; RNP = ribonucleoprotein.

ISSN: 1478-6362