|
Quantitative traits
|
Clinical data
|
|---|
|
Age at disease onset
|
n
|
Mean ± SD (years)
|
P*
|
|
Total
|
781
|
47.7 (14.2)
| |
|
Anti-centromere
|
273
|
51.3 (12.5)
|
< 0.0001
|
|
Anti-topoisomerase I
|
238
|
46.0 (14.0)
|
0.0076
|
|
Anti-fibrillarin
|
12
|
38.8 (16.0)
|
0.0404
|
|
Anti-U1-RNP
|
39
|
38.2 (15.0)
|
< 0.0001
|
|
Anti-La
|
15
|
37.9 (18.1)
|
0.0431
|
|
Autoantibody-negative
|
36
|
52.9 (14.7)
|
0.0205
|
|
Rodnan skin score
|
n
|
Mean score ± SD
|
P
|
|
Total
|
750
|
10.2 (9.4)
| |
|
Anti-centromere
|
275
|
6.4 (6.0)
|
< 0.0001
|
|
Anti-topoisomerase I
|
227
|
14.1 (9.7)
|
< 0.0001
|
|
Anti-RNA polymerase
|
27
|
15.7 (11.7)
|
0.0091
|
|
Anti-fibrillarin
|
10
|
21.2 (15.0)
|
0.0108
|
|
Anti-U1-RNP
|
35
|
6.9 (9.2)
|
0.0053
|
|
Erythrocyte sedimentation rate
|
n
|
Mean ± SD (mm/hour)
|
P
|
|
Total
|
741
|
19.46 (16.7)
| |
|
Anti-topoisomerase I
|
227
|
22.95 (19.1)
|
0.0002
|
|
Anti-PM-Scl
|
36
|
12.19 (9.4)
|
0.0014
|
|
Anti-Ro52
|
167
|
22.05 (18.8)
|
0.0374
|
|
Anti-Ro60
|
53
|
28.47 (19.6)
|
< 0.0001
|
|
Anti-La
|
16
|
28.56 (20.1)
|
0.0447
|
- PM-Scl = polymyositis and scleroderma; RNP = ribonucleoprotein; SSc, systemic sclerosis. *P-value calculated by Mann-Whitney rank-sum test for comparison of antibody-positive vs antibody-negative patients.
