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Table 2 sRANKL, OPG and sRANKL/OPG ratio levels in SLE patients and healthy controls

From: Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients

  SLE patients Healthy controls P-value
sRANKL 0.40 (0.02 to 25.99) 0.40 (0.29 to 67.64) 0.372
OPG 69.02 (17.42 to 500.90) 95.14 (1.56 to 1069.13) < 0.001
sRANKL/OPG ratio 0.0103 (0.001 to 0.817) 0.0056 (0.000 to 1.866) 0.010
  1. Values represent median (IQR). Differences were assessed by non-parametric Mann-Whitney U test.
  2. In 49.5% of SLE patients and 63.2% of healthy controls, the sRANKL levels were below the limit of detection (LOD) of the quantification method. Regarding OPG quantification, there were no samples with concentrations below the LOD.
  3. IQR, interquartile range; OPG, osteoprotegerin; SLE, Systemic Lupus Erythematosus; sRANKL, soluble RANKL