Table 3 Predictors of sRANKL, OPG and sRANKL/OPG ratio levels in SLE patients (after multivariate analysis)
Possible predictors | log(sRANKL) | log(OPG) | log(sRANKL/OPG ratio) | |||
|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis‡ | Univariate analysis | Multivariate analysis§ | Univariate analysis | Multivariate analysis* | |
β coefficient (95% CI) | β coefficient (95% CI) | β coefficient (95% CI) | β coefficient (95% CI) | β coefficient (95% CI) | β coefficient (95% CI) | |
P- value | P- value | P- value | P- value | P- value | P- value | |
Age | -0.304 (-0.049 to -0.012) | -0.232 (-0.043 to -0.004) | 0.218 (0.001 to 0.015) | -0.363 (-0.058 to -0.019) | -0.326 (-0.065 to -0.015) | |
0.002 | 0.017 | 0.027 | < 0.001 | 0.001 | ||
BMI | -0.249 (-0.126 to -0.016) | -0.211 (-0.123 to -0.005) | ||||
0.011 | 0.033 | |||||
Menopausal status | -0.210 (-1.131 to -0.006) | 0.211 (0.003 to 0.439) | -0.274 (-1.379 to -0.200) | |||
0.048 | 0.047 | 0.009 | ||||
Lipid lowering therapy | -0.214 (-1.451 to -0.068) | |||||
0.032 | ||||||
Antihypertensive therapy | 0.217 (0.026 to 0.438) 0.028 | |||||
Diabetes mellitus | 0.271 (0.198 to 1.122) | 0.247 (0.117 to 0.984) | ||||
0.006 | 0.013 | |||||
Triglycerides | 0.266 (0.000 to 0.003) | 0.306 (0.001 to 0.004) | ||||
0.011 | 0.02 | |||||
Age at disease onset | -0.268 (-0.045 to -0.008) | 0.237 (0.002 to 0.016) | -0.335 (-0.054 to -0.016) | |||
0.006 | 0.016 | 0.001 | ||||
Malar rash | 0.251 (0.166 to 1.246) | 0.243 (0.150 to 1.230) | 0.201 (0.019 to 1.178) | |||
0.011 | 0.013 | 0.043 | ||||
Arthritis | -0.272 (-0.556 to -0.098) | |||||
0.005 | ||||||
Pleuritis | -0.197 (-1.555 to -0.010) | |||||
0.047 | ||||||
Anti-Sm titers | 0.224 (0.003 to 0.051) | 0.227 (0.005 to 0.051) | 0.264 (0.009 to 0.059) | 0.229 (0.006 to 0.053) | ||
0.026 | 0.018 | 0.008 | 0.016 | |||
Anti-dsDNA titers | 0.204 (0.000 to 0.007) | -0.208 (-0.003 to 0.000) | -0.239 (-0.004 to 0.000) | 0.268 (0.001 to 0.009) | ||
0.047 | 0.043 | 0.016 | 0.009 | |||