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Table 3 Predictors of sRANKL, OPG and sRANKL/OPG ratio levels in SLE patients (after multivariate analysis)

From: Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients

Possible predictors log(sRANKL) log(OPG) log(sRANKL/OPG ratio)
  Univariate analysis Multivariate analysis‡ Univariate analysis Multivariate analysis§ Univariate analysis Multivariate
analysis*
  β coefficient (95% CI) β coefficient
(95% CI) 		β coefficient (95% CI) β coefficient (95% CI) β coefficient (95% CI) β coefficient
(95% CI)
  P- value P- value P- value P- value P- value P- value
Age -0.304
(-0.049 to -0.012) 		-0.232
(-0.043 to -0.004) 		0.218
(0.001 to 0.015) 		  -0.363
(-0.058 to -0.019) 		-0.326
(-0.065 to -0.015)
  0.002 0.017 0.027   < 0.001 0.001
BMI -0.249
(-0.126 to -0.016) 		    -0.211
(-0.123 to -0.005) 		 
  0.011     0.033  
Menopausal status -0.210
(-1.131 to -0.006) 		  0.211
(0.003 to 0.439) 		  -0.274
(-1.379 to -0.200) 		 
  0.048   0.047   0.009  
Lipid lowering therapy      -0.214
(-1.451 to -0.068) 		 
      0.032  
Antihypertensive therapy    0.217
(0.026 to 0.438)
0.028 		   
Diabetes mellitus    0.271
(0.198 to 1.122) 		0.247
(0.117 to 0.984) 		  
    0.006 0.013   
Triglycerides    0.266
(0.000 to 0.003) 		0.306
(0.001 to 0.004) 		  
    0.011 0.02   
Age at disease onset -0.268
(-0.045 to -0.008) 		  0.237
(0.002 to 0.016) 		  -0.335
(-0.054 to -0.016) 		 
  0.006   0.016   0.001  
Malar rash 0.251
(0.166 to 1.246) 		0.243
(0.150 to 1.230) 		   0.201
(0.019 to 1.178) 		 
  0.011 0.013    0.043  
Arthritis    -0.272
(-0.556 to -0.098) 		   
    0.005    
Pleuritis      -0.197
(-1.555 to -0.010) 		 
      0.047  
Anti-Sm titers 0.224
(0.003 to 0.051) 		0.227
(0.005 to 0.051) 		   0.264
(0.009 to 0.059) 		0.229
(0.006 to 0.053)
  0.026 0.018    0.008 0.016
Anti-dsDNA titers 0.204
(0.000 to 0.007) 		  -0.208
(-0.003 to 0.000) 		-0.239
(-0.004 to 0.000) 		0.268
(0.001 to 0.009) 		 
  0.047   0.043 0.016 0.009  
  1. Multivariate analysis results from multiple linear regression analysis. The total explained variance of the model is (‡) R2 = 0.185, (§) R2 = 0.237, and (*) R2 = 0.175.
  2. OPG, osteoprotegerin; SLE, Systemic Lupus Erythematosus; sRANKL, soluble RANKL
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Arthritis Research & Therapy

ISSN: 1478-6362

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