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Table 1 Median (range) of the laboratory, clinical and US scores

From: The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab

  Baseline 1 month 3 months 6 months 12 months
Calprotectin, mg/l (normal ≤ 0.9l) 2.02 (0.56 to 20.44) 0.92 (0.32 to 18.86)** 0.93 (0.28 to 6.30)** 0.94 (0.24 to 22.02)** 1.08 (0.36 to 17.60)
SAA mg/l (normal
≤ 6.4)
10.60 (2.17 to 300) 6.94 (1.37 to 270)* 4.19 (0.70 to 38.5)** 4.39 (1.61 to 176)* 8.37 (1.12 to 136)
CRP, mg/l
(normal ≤ 4)
4.5 (1 to 136) 2.0 (1 to 163) 2.5 (1 to 26)** 2.5 (1 to 78) 4.5 (1 to 86)
ESR, mm/h
(normal ≤ 20)
20 (3 to 67) 13 (3 to 108)** 14.5 (2 to 65)** 14.5 (5 to 99) 17.5 (3 to 78)
DAS28 5.32 (3.40 to 7.70) 4.20 (1.56 to 8.90)** 4.26 (0.83 to 7.02) ** 4.36 (1.59 to 7.58)** 4.33 (1.40 to 6.60)**
Assessors VAS 26 (6 to 55) 15 (4 to 52)* 14 (3 to 40)** 11 (2 to 57) 10 (3 to 44)**
No of swollen joints (of 40) 8 (1 to 19) 5 (0 to 22) 6 (0 to 16)** 4 (0 to 16)* 4 (0 to 14)**
No of tender joints (of 40) 12 (0 to 23) 9 (0 to 35) 7 (0 to 16)** 6 (0 to 16)** 7 (0 to 21)**
BM score 53 (6 to 151) 39 (3 to 121)** 35 (6 to 94)** 24 (0 to 86)** 27 (1 to 96)**
PD score 33 (0 to 119) 21 (0 to 83)** 16 (2 to 53)** 14 (0 to 76)** 13 (0 to 72)**
  1. *P < 0.05, **P < 0.01 (Wilcoxon signed rank test for changes from baseline to the different follow-up examinations).
  2. BM, B-mode; CRP, C-reactive protein; DAS28, Disease Activity Score 28 joints; ESR, erythrocyte sedimentation rate; PD, power Doppler; SAA, serum amyloid A; Assessors VAS, assessors global disease activity score on a visual analogue scale (0 to 100).