Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population

Table 1 SNP association analysis of the 18 SNPs in all cases and controls

Gene and SNP	Position ^a	Minor allele	Minor allele frequency		P value	Corrected P value ^b	Odds ratio (95% confidence interval)
			Case	Control
FCGR3A
rs11581823	1:161517384	C	0.0830	0.0975	0.28		0.84 (0.62 to 1.14)
rs7539036	1:161512731	T	0.0580	0.0714	0.25		0.80 (0.56 to 1.14)
FCGR2A
rs4656308	1:161478751	C	0.1602	0.1456	0.36		1.12 (0.88 to 1.42)
rs1801274	1:161479745	G	0.3565	0.34	0.43		1.08 (0.90 to 1.29)
TNFAIP3
rs5029924	6:138187498	T	0.0817	0.0470	0.0017	0.030	1.80 (1.25 to 2.61)
rs5029937	6:138195151	T	0.0812	0.0448	0.0006	0.012	1.88 (1.30 to 2.73)
rs2230926	6:138196066	G	0.0811	0.0448	0.0007	0.012	1.88 (1.30 to 2.72)
rs610604	6:138199417	G	0.0989	0.0984	1.00		1.00 (0.75 to 1.34)
TLR9
rs187084	3:52261031	C	0.3773	0.3722	0.82		1.02 (0.85 to 1.22)
rs352140	3:52256697	A	0.3686	0.3635	0.82		1.02 (0.86 to 1.22)
rs352162	3:52252969	G	0.3850	0.3770	0.72		1.04 (0.87 to 1.24)
TREX1
rs2242150	3:48505964	A	0.3535	0.3340	0.35		1.09(0.91 to 1.31)
rs3135941	3:48507667	C	0.0326	0.0392	0.47		0.82 (0.52 to 1.32)
ETS1
rs6590330	11:128311059	A	0.4258	0.3086	3.0 × 10^-8	5.5 × 10 ^-7	1.66 (1.39 to 1.99)
rs4937333	11:128330520	T	0.4814	0.3652	9.3 × 10 ^-8	1.7 × 10 ^-6	1.61 (1.35 to 1.92)
TNIP1
rs13168551	5:150462638	T	0.2211	0.2505	0.14		0.85 (0.69 to 1.05)
rs7708392	5:150457485	G	0.2132	0.2587	0.02	0.39	0.78 (0.63 to 0.96)
rs10036748	5:150458146	C	0.2196	0.2552	0.08		0.82 (0.66 to 1.02)

Bold data are significant. ^aGenomic positions from NCBI Genome Build 37.1 (GRCh37) [56]. ^bP values calculated by Fisher's exact test and then corrected by the Bonferroni criterion.

ISSN: 1478-6362