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Table 5 Baseline characteristics of male OA patients according to serum FSTL1 levels.

From: Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis

  Male serum FSTL1 levels (μg/L)   
  First quartile Second quartile Third quartile Fourth quartile P r
  (1.19-3.81) (3.81-5.40) (5.88-8.62) (8.79-16.88)   
Number 12 12 12 12   
Age (years) 58 (47-61) 60 (54-74) 58 (52-72) 69 (65-79) 0.005 0.396
Disease duration (years) 0.1 (0.1-1.7) 0.6 (0.2-4.8) 1.5 (0.5-3.8) 2.5 (0.2-6.8) 0.004 0.405
Height, cm 170 (166-174) 168 (166-170) 166 (162-170) 169 (168-170) 0.378 -0.130
Weight, kg 72 (66-76) 68 (64-76) 67 (60-75) 69 (61-77) 0.376 -0.131
BMI 24.2 (22.8-26.2) 24.6 (22.7-26.3) 24.0 (21.6-25.8) 24.0 (21.4-26.4) 0.511 -0.097
Single/dual knee (hip) 11/1 12/0 9/3 9/3 0.130 0.222
Hypertension 4 (33%) 5 (42%) 5 (42%) 6 (50%) 0.486 0.103
Diabetes 2 (17%) 1 (8%) 1 (8%) 3 (25%) 0.687 0.060
Hs-CRP (mg/L) 1.4 (0.7-1.9) 1.1 (0.4-10.7) 1.4 (0.6-2.9) 2.4 (0.7-15.5) 0.056 0.278
ESRa 8 (3-10) 4 (3-13) 5 (5-20) 12 (2-27) 0.957 -0.009
RF 3.8 (0.3-10.6) 7.2 (4.8-18.7) 11.1 (6.0-18.8) 9.0 (7.4-16.3) 0.021 0.332
Pain (VAS mm)b 55 (40-60) 50 (20-70) 50 (35-80) 50 (40-80) 0.371 0.145
WOMAC score (all normalized/100)c      
Pain subscale 64 (57-68) 64 (64-71) 60 (51-68) 59 (52-61) 0.407 -0.152
Stiffness subscale 58 (46-75) 61 (45-81) 49 (45-79) 54 (43-58) 0.636 -0.087
Function subscale 65 (54-83) 77 (46-90) 69 (35-90) 60 (52-65) 0.617 -0.092
Total Score 63 (55-85) 69 (51-80) 63 (44-78) 59 (52-63) 0.342 -0.168
KL grade (0-4) 5/4/2/0/2 4/2/3/1/2 3/1/5/1/2 2/2/4/1/3 0.069 0.265
JSN 2 (17%) 3 (25%) 3 (25%) 4 (33%) 0.127 0.224
  1. Data are number (%) or median (25th to 75th percentile). Linear regression was used to evaluate the relationships between FSTL1 and baseline characteristics and to calculate P values and the correlation coefficient, r. (Serum FSTL1 levels, disease duration, hs-CRP, ESR and RF in the male OA patients were not normally distributed and were entered as ln-transformed variables). aData from ESR were available for 39 patients; bData for Pain VAS were available for 40 patients; cData from the total WOMAC score were available for 34 patients, and the pain subscale, stiffness subscale and function subscale were available for 32 patients, respectively. BMI, body mass index; ESR, erythrocyte sedimentation rate; FSTL1, follistatin-like protein 1; Hs-CRP, high sensitivity C-reactive protein; JSN, joint space narrowing; KL, Kellgren and Lawrence; OA, osteoarthritis; RF, rheumatoid factor; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities.