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Table 3 Differential protein spots from pSS, healthy volunteers and non-SS sicca syndrome patients (P <0

From: Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes

Spot No Accession No Protein name Gene name Mean ± SD
(pSS)
Mean ± SD
(healthy)
Mean ± SD
(sicca non-SS)
Fold of variation
pSS vshealthy
Fold of variation
pSS vssicca non-SS
2261 P04745 α-amylases precursor AMY1A 2.58 ± 0.44 4.77 ± 0.39 4.24 ± 0.67 -1.8** -1.6**
2572 Q5FC00 Carbonic anhydrase VI CA6 0.65 ± 0.11 1.50 ± 0.47 1.07 ± 0.26 -2.3* -1.6*
2642 P04406 G3PDH GAPDH 0.07 ± 0.03 0.31 ± 0.03 0.23 ± 0.85 -4.4*** -3.2*
2543 P06733 α-enolase ENO1 0.08 ± 0.02 0.04 ± 0.01 0.05 ± 0.03 +2** +1.6
2842 Q6GMW1 IGKC IGKC 1.33 ± 0.49 0.17 ± 0.30 0.54 ± 0.42 +7.8* +2.5
3018 P31151 Protein S100-A7 (Psoriasin) S100A7 0.47 ± 0.21 0.09 ± 0.04 0.32 ± 0.15 +5.2* +1.5
3000 P06702 Protein S100-A9 (Calgranulin B) S100A9 2.98 ± 0.10 2.00 ± 0.42 2.75 ± 0.54 +1.5* ns
2986 P01037 Cystatin SN precursor CST1 0.91 ± 0.36 2.37 ± 0.01 0.84 ± 0.44 -2.6** ns
2938 P12273 PIP PIP 0.05 ± 0.08 0.33 ± 0.01 0.09 ± 0.17 -6.6** -1.8
2655 Q96DR5 SPLUNC-2 SPLUNC2 0.04 ± 0.07 0.40 ± 0.17 0.40 ± 0.18 -10* -10*
3003 Q01469 E-FABP FABP5 0.17 ± 0.07 0.02 ± 0.03 0.06 ± 0.05 +8.5* +2.8*
3036 P61769 β-2 microglobulin B2M 0.39 ± 0.04 0.17 ± 0.04 0.23 ± 0.05 +2.3** +1.7
  1. NB, values that are significantly different from pSS (*P <0.05, **P <0.01, ***P <0.001) as determined by statistical analysis. E-FABP, epidermal fatty acid binding protein; G3PDH, glyceraldehydes-3-phosphate dehydrogenase; IGKC, immunoglobulin k light chain; PIP, prolactin-inducible protein precursor; pSS, primary Sjögren's syndrome; SPLUNC-2, lung and nasal epithelium clone 2; SS, Sjögren's syndrome