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Table 4 Differential protein spots in pSS, RA-sSS and SSc-sSS (P <0

From: Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes

Spot No

Accession No

Protein name

Gene name

Mean ± SD

(pSS)

Mean ± SD

(RA- sSS)

Mean ± SD

(SSc-sSS)

Fold of variation

pSS vsRA- sSS

Fold of variation

pSS vsSSc-sSS

3017

P06702

(Protein S100-A9)

Calgranulin B

S100A9

0.15 ± 0.07

0.37 ± 0.07

-

-2.46*

-

3034

P06702

(Protein S100-A9)

Calgranulin B

S100A9

0.20 ± 0.09

0.56 ± 0.17

-

-2.8*

-

2439

P06733

α-enolase

ENO1

0.13 ± 0.02

0.05 ± 0.02

-

+2.6**

-

2543

P06733

α-enolase

ENO1

0.08 ± 0.02

0.19 ± 0.03

-

-2.4**

-

2842

Q6GMW1

IGKC

IGKC

1.33 ± 0.49

0.05 ± 0.09

-

+26*

-

2832

A0N5G5

Rheumatoid factor D5

light chain

V<KAPPA>3

1.97 ± 0.11

0.29 ± 0.26

-

+6.8***

-

2954

P31025

Lipocalin

LCN1

0.06 ± 0.05

0.37 ± 0.07

-

-6.2**

-

3036

P61769

β-2 microglobulin

B2M

0.39 ± 0.04

0.25 ± 0.04

0.25 ± 0.03

+1.6*

+1.6*

2642

P04406

G3PDH

G3PDH

0.07 ± 0.03

-

0.19 ± 0.10

-

-2.7*

2996

P01034

Cystatin-C

CST3

0.21 ± 0.08

-

0.05 ± 0.04

-

-4.2*

  1. NB, values that are significantly different from pSS (*P <0.05, **P <0.01, ***P <0.001) as determined by statistical analysis.
  2. G3PDH, glyceraldehydes-3-phosphate dehydrogenase; IGKC, immunoglobulin k light chain; pSS, primary Sjögren's syndrome; RA-sSS, secondary Sjögren's syndrome concomitant to rheumatoid arthritis; SSc-sSS, secondary Sjögren's syndrome concomitant to systemic sclerosis