Micro-CT analysis of knee joints after meniscal-ligamentous injury (MLI) as a function of diet. (a) Knee-bone volumes of MLI and sham-treated limbs at 3 months in HF, Lean to HF, and Lean diet groups were analyzed with micro-CT. (b) Three-dimensional reconstructions of knee joints were used to visualize calcification of meniscus and osteophyte formation. Gray arrows, ossification of meniscus; white arrows, osteophyte-like structures. Representative 3D images are presented. Bone volume data represent the mean ± SEM of at least five mice. **P < 0.01. n = 6 to 8 mice in each group.