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Table 3 Associations of haplotypes in CD46 with SLE and SLE nephritis

From: Mutations in genes encoding complement inhibitors CD46 and CFHaffect the age at nephritis onset in patients with systemic lupus erythematosus

   Frequency SLE nephritis versus healthy controls SLE versus healthy controls
Cohort CD46haplotype All SLE patients SLE with nephritis SLE without nephritis Healthy controls Odds ratio Pvalue Odds ratio Pvalue
Southern Sweden GGAAC 0.3068 0.2457 0.3271 0.3512 0.60 0.076 0.81 0.22
Southern Sweden AGAAC 0.0901 0.0418 0.1062 0.0573 0.66 0.52 1.53 0.17
Southern Sweden GAGGT 0.0901 0.0918 0.0895 0.0627 1.59 0.34 1.41 0.26
Southern Sweden AAGGT 0.4974 0.5707 0.473 0.5099 1.3 0.31 0.99 0.93
Mid Sweden GGAAC 0.3242 0.3251 0.3238 0.37 0.81 0.18 0.82 0.090
Mid Sweden AGAAC 0.0892 0.112 0.0723 0.0643 1.93 0.011 1.45 0.093
Mid Sweden GAGGT 0.0636 0.0555 0.0695 0.0647 0.84 0.60 0.96 0.84
Mid Sweden AAGGT 0.5117 0.5005 0.5204 0.4875 1.07 0.68 1.12 0.34
Combined cohort GGAAC 0.3184 0.3063 0.3255 0.3633 0.76 0.047 0.82 0.044
Combined cohort AGAAC 0.0895 0.096 0.0856 0.0618 1.59 0.056 1.48 0.030
Combined cohort GAGGT 0.0725 0.0644 0.0772 0.0641 1 1 1.09 0.64
Combined cohort AAGGT 0.5069 0.5161 0.5017 0.4954 1.12 0.38 1.07 0.48
  1. SLE, systemic lupus erythematosus.