Mutations in genes encoding complement inhibitors CD46 and CFHaffect the age at nephritis onset in patients with systemic lupus erythematosus

Table 3 Associations of haplotypes in CD46 with SLE and SLE nephritis

		Frequency				SLE nephritis versus healthy controls		SLE versus healthy controls
Cohort	*CD46*haplotype	All SLE patients	SLE with nephritis	SLE without nephritis	Healthy controls	Odds ratio	Pvalue	Odds ratio	Pvalue
Southern Sweden	GGAAC	0.3068	0.2457	0.3271	0.3512	0.60	0.076	0.81	0.22
Southern Sweden	AGAAC	0.0901	0.0418	0.1062	0.0573	0.66	0.52	1.53	0.17
Southern Sweden	GAGGT	0.0901	0.0918	0.0895	0.0627	1.59	0.34	1.41	0.26
Southern Sweden	AAGGT	0.4974	0.5707	0.473	0.5099	1.3	0.31	0.99	0.93
Mid Sweden	GGAAC	0.3242	0.3251	0.3238	0.37	0.81	0.18	0.82	0.090
Mid Sweden	AGAAC	0.0892	0.112	0.0723	0.0643	1.93	0.011	1.45	0.093
Mid Sweden	GAGGT	0.0636	0.0555	0.0695	0.0647	0.84	0.60	0.96	0.84
Mid Sweden	AAGGT	0.5117	0.5005	0.5204	0.4875	1.07	0.68	1.12	0.34
Combined cohort	GGAAC	0.3184	0.3063	0.3255	0.3633	0.76	0.047	0.82	0.044
Combined cohort	AGAAC	0.0895	0.096	0.0856	0.0618	1.59	0.056	1.48	0.030
Combined cohort	GAGGT	0.0725	0.0644	0.0772	0.0641	1	1	1.09	0.64
Combined cohort	AAGGT	0.5069	0.5161	0.5017	0.4954	1.12	0.38	1.07	0.48

ISSN: 1478-6362