Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis

Table 2 Tibial subchondral plate thickness and porosity of the MIA-injected knee and control knee, at 2, 6, and 10 weeks post-MIA injection.

	Subchondral Plate Thickness, Pl.Th (μm)									Subchondral Plate Porosity, Pl.Por (%)
	Medial			Lateral			Total			Medial		Lateral		Total
										% d		% d		% d
	OA	Control	p-value	OA	Control	p-value	OA	Control	p-value	OA - CTL	p-value	OA - CTL	p-value	OA - CTL	p-value
2 weeks	114 ± 7	105 ± 7	0.027	101 ± 6	109 ± 7	0.305	107 ± 4	107 ± 8	0.770	23	0.004	24	0.004	24	0.003
6 weeks	146 ± 32	119 ± 32	0.024	130 ± 17	120 ± 26	0.880	138 ± 23	118 ± 26	0.028	63	0.001	69	p < 0.001	66	p < 0.001
10 weeks	181 ± 27	175 ± 31	0.520	166 ± 18	178 ± 24	0.318	177 ± 19	177 ± 25	0.473	66	0.004	77	0.004	71	0.003

Data represented as mean ± SD for plate thickness, % d is the percentage difference in plate porosity between the control and MIA-injected knee. MIA, monosodium iodoacetate; OA, osteoarthritis; OA-CTL, osteoarthritis control; SD, standard deviation

ISSN: 1478-6362