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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis

Figure 1

Effect of Nav1.8 ion channel blockade on joint nociception. Figure shows a typical single unit recording of an unmyelinated C-fiber (conduction velocity: 1.38 m/sec) in response to normal and noxious rotation of MIA arthritic knee joints. Recording shows nerve firing activity before (A) and after (B) close intra-arterial injection of A-803467. Coincidental torque levels are displayed below each nerve recording. Movement-evoked afferent firing rate was reduced by local administration of the Nav1.8 ion channel blocker.

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