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Table 2 PANTHER analysis of differentially expressed genes by pathway.
| Pathway | number of genes in reference list | number of regulated genes | Expected number of genes | P-value* |
|---|---|---|---|---|
| Pathways that are overrepresented taking up-regulated genes into account | ||||
| Integrin signaling pathway | 185 | 19 | 3.48 | 4.78E-09 |
| WNT signaling pathway | 348 | 22 | 6.55 | 1.27E-06 |
| Angiogenesis | 193 | 12 | 3.63 | 3.76E-04 |
| Cadherin signaling pathway | 167 | 11 | 3.14 | 4.07E-04 |
| Alzheimer disease-presenilin pathway | 124 | 9 | 2.33 | 6.84E-04 |
| Pathways that are overrepresented taking downregulated genes into account | ||||
| B cell activation | 87 | 21 | 3.01 | 1.03E-11 |
| p53 pathway | 127 | 18 | 4.39 | 8.32E-07 |
| Inflammation mediated by chemokine and cytokine signaling pathway | 298 | 29 | 10.30 | 1.12E-06 |
| Blood coagulation | 55 | 10 | 1.90 | 2.96E-05 |
| p53 pathway feedback loops 2 | 51 | 9 | 1.76 | 9.15E-05 |
| Parkinson disease | 106 | 13 | 3.66 | 1.13E-04 |
| Cell cycle | 24 | 6 | 0.83 | 2.21E-04 |
| Integrin signaling pathway | 185 | 17 | 6.39 | 3.38E-04 |
| De novo pyrimidine deoxyribonucleotide biosynthesis | 23 | 5 | 0.79 | 1.36E-03 |
| DNA replication | 25 | 5 | 0.86 | 1.95E-03 |
| Ras Pathway | 80 | 9 | 2.76 | 2.20E-03 |
| Apoptosis signaling pathway | 141 | 12 | 4.87 | 4.37E-03 |
| T cell activation | 142 | 12 | 4.91 | 4.61E-03 |
| JAK/STAT signaling pathway | 20 | 4 | 0.69 | 5.48E-03 |
| Angiogenesis | 193 | 14 | 6.67 | 8.51E-03 |
| Pathways that are overrepresented taking up- and down-regulated genes into account | ||||
| Integrin signaling pathway | 185 | 36 | 9.87 | 7.87E-09 |
| B cell activation | 87 | 24 | 4.64 | 7.10E-09 |
| Inflammation mediated by chemokine and cytokine signaling pathway | 298 | 41 | 15.90 | 2.42E-06 |
| p53 pathway | 127 | 21 | 6.78 | 1.79E-04 |
| Angiogenesis | 193 | 26 | 10.30 | 4.45E-04 |
| Blood coagulation | 55 | 12 | 2.93 | 8.00E-04 |
| p53 pathway feedback loops 2 | 51 | 9 | 2.72 | 2.42E-02 |
| Cell cycle | 24 | 6 | 1.28 | 2.19E-02 |
| WNT signaling pathway | 348 | 31 | 18.57 | 4.57E-02 |
| Axon guidance mediated by netrin | 29 | 6 | 1.55 | 4.36E-02 |
| Parkinson disease | 106 | 13 | 5.66 | 4.22E-02 |
