Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1shared epitope alleles

Table 1 Sequences of synthetic fibronectin peptides

Peptide name	Peptides identified in RA SF^a	Synthetic peptide^a	Citrulline residues identified in RA1	Citrulline residues identified in RA2
FN-Cit₂₄₁	DTRTSYXIGDTWSK, TSYXIGDTWSK	DTRTSYXIGDTWSZO	X	X
FN-Arg₂₄₁		DTRTSYRIGDTWSZO
FN-Cit_1035,1036	LTVGLTXXGQPR, AQITGYRLTVGLTXR	LTVGLTXXGQPRQYZO	X	X^b
FN-Arg_1035,1036		LTVGLTRRGQPRQYZO
FN-Cit₁₁₆₂	DGQEXDAPIVNK	LRDGQEXDAPIVNZO	X	X
FN-Arg₁₁₆₂		LRDGQERDAPIVNZO
FN-Cit₂₃₅₆	RPGGEPSPEGTTGQSYNQYSQXYHQR	YNQYSQXYHQRTNZO		X
FN-Arg₂₃₅₆		YNQYSQRYHQRTNZO

^a O, biotinylated lysine; X, citrulline; Z, aminohexanoic acid. ^b Only citrulline at position 1035 was identified

ISSN: 1478-6362