Skip to main content

Advertisement

Table 4 Multivariable Cox regression model adjusted for age, arterial disease and cystatin C (208 patients).

From: Risk factors for cardiovascular mortality in patients with systemic lupus erythematosus, a prospective cohort study

  OM   CVM   N-VM  
  P-value HR (95% CI) P-value HR (95% CI) P-value HR (95% CI)
Smoking    0.02 3.4 (1.3-9.2)   
SLICC>1[25] 0.008 4.1 (1.4-17.3)    0.05 5.6 (1.0-103.6)
2GP1    0.03 3.4 (1.2-9.7)   
Any aPL medium titer    0.05 2.8 (1.0-8.2)   
Sjogrens syndrome B antibodies      0.02 1.3e-6 (0-0.7)
Warfarin    0.05 3.4 (1.0-10.4)   
High sensitivity CRP 0.04 1.3 (1.0-1.6) 0.02 1.6 (1.1-2.3)   
Fibrinogen 0.04 3.7 (1.0-13.1)    0.05 6.7 (1.0-45.4)
α-1-antitrypsine 0.007 2.7 (1.3-5.2)    0.004 4.3 (1.6-10.7)
Soluble vascular cell adhesion molecule 1 0.05 2.7 (1.0-6.7) 0.02 5.3 (1.3-19.3)   
  1. 2GP1, anti-β2 glycoprotein-1; any aPL, any antiphospholipid; positive antibody against cardiolipin IgG/IgM at medium titer, β2GP1 or a positive lupus anticoagulant test; OM, overall mortality; CVM, cardiovascular mortality; HR, hazard ratio; N-VM, non-vascular mortality; SLICC, systemic lupus international collaborating clinics. Age, arterial disease and cystatin C were included in all multivariable models. Each variable that was significant in age-adjusted Cox regression (Table 3) for OM, CVM and N-VM, was included one by one, together with the three above-mentioned variables, creating a model with four variables. The table presents the results of the significant associations. Only variables that have P-values ≤ 0.05 in either group are presented. In this way, five different multivariable models are presented for OM, six for CVM, and four for N-VM, respectively.