Effect of CS on IL-1β-dependent VEGI and TSP-1 production. SFC were pre-incubated with CS (10, 50, 200 μg/ml) for 1 h. IL-1β (1 ng/ml) was added to culture medium for 24 h. TSP-1 and VEGI were measured in conditioned culture supernatants by ELISA. Results are normalized to DNA content. Results are expressed as a percentage of the control (cells incubated without CS). Each condition was tested in triplicate. Results are expressed as mean ± SD of three independent experiments. Comparison of mean values was performed by Mann-Whitney non-parametric analysis. ***P < 0.001: CS treated group was significantly different from control.