Table 1 Comparison of the success of antibodies to Ro52, Ro60, or La at inducing heart block in experimental models
From: Congenital heart block: evidence for a pathogenic role of maternal autoantibodies
Inducing factor | Species (strain) | Proportion of AVB, percentagea | AVB II/III, percentagea | Reference |
|---|---|---|---|---|
Antibody transfer during gestation (specificity/antigen) | ||||
Ro52 and Ro60 | Mouse (BALB/c) | 47-100 | 0 | Mazel, et al. [58] (1998) |
Ro52/p200 (aa 200-239) | Rat (DA) | 100 | 0 | Ambrosi, et al. [59] (2012) |
Ro52/N- or C-terminal | Rat (DA) | 0 | 0 | Â |
Immunization before gestation (specificity/antigen) | ||||
Ro52 | Mouse (BALB/c) | 25 | 10 | Boutjdir, et al. [50] (1997) |
Ro52 | Mouse (BALB/c) | 9 | 3.6 | Miranda-Carus, et al. [53] (1998) |
Ro52 | Rabbit (New Zealand) | 9 | 0.7 (20% pups born dead) | Xiao, et al. [56] (2001) |
Ro52 | Rat (DA) | 45 | 0 | Strandberg, et al. [55] (2010) |
| Â | Rat (LEW) | 10 | 0 | Â |
| Â | Rat (PVG) | 44 | 0 | Â |
Ro52β | Mouse (BALB/c) | 12 | 6 | Miranda-Carus, et al. [53] (1998) |
Ro52 (mouse) | Mouse (BALB/c) | 9 | 0 | Â |
Ro52 (aa 365-382) | Mouse (BALB/c) | 0 | 0 | Eftekhari, et al. [64] (2001) |
Ro52 (aa 366-379) | Mouse (BALB/c) | 0 | 0 | Â |
Ro52/p200 (aa 200-239) | Rat (DA) | 19 | 0 | Salomonsson, et al. [45] (2005) |
Ro60 | Mouse (BALB/c) | 19 | 0 | Miranda-Carus, et al. [53] (1998) |
Ro60b | Mouse (C3H/HEJ) | 14 | 0 | Suzuki, et al. [54] (2005) |
La | Mouse (BALB/c) | 7 | 0 | Miranda-Carus, et al. [53] (1998) |
Lab | Mouse (C3H/HEJ) | 7 | 0 | Suzuki, et al. [54] (2005) |
Ro52, Ro60, and La | Mouse (FBV Cav1.2 non-transgenic littermates) | 28 | 5.5 | Karnabi, et al. [68] (2011) |
| Â | Mouse (FBV Cav1.2 transgenic) | 9 | 1.1 | Â |
| Â | Mouse (C57BL/6 Cav1.3+/+) | 18 | 3 | Â |
| Â | Mouse (C57BL/6 Cav1.3-/-) | 100 | 44 | Â |