Genotype, N (%) | Allele test | ||||||||
---|---|---|---|---|---|---|---|---|---|
SNP | Subgroup (N) | 1/1 | 1/2 | 2/2 | MAF (%) | P MH | P FDR_BH | OR [CI 95%] | P BD |
rs763361 | Controls (n = 3811) | 906 (23.77) | 1841 (48.31) | 1064 (27.92) | 47.93 | ||||
SSc (n = 2023) | 480 (23.73) | 990 (48.94) | 553 (27.34) | 48.2 | 0.56 | 0.73 | 1.02 [0.95-1.10] | 0.56 | |
lcSSc (n = 1397) | 332 (23.77) | 681 (48.75) | 384 (27.49) | 48.14 | 0.64 | 0.95 | 1.02 [0.94-1.11] | 0.8 | |
dcSSc (n = 626) | 148 (23.64) | 309 (49.36) | 169 (27.00) | 48.32 | 0.6 | 0.94 | 1.03 [0.92-1.17] | 0.14 | |
ACA+ (n = 797) | 176 (22.08) | 396 (49.69) | 225 (28.23) | 46.93 | 0.68 | 0.68 | 0.98 [0.88-1.09] | 0.85 | |
ATA+ (n = 503) | 133 (26.44) | 239 (47.51) | 131 (26.04) | 50.2 | 0.22 | 0.28 | 1.09 [0.95-1.24] | 0.63 | |
Fib+ (n = 729) | 176 (24.14) | 359 (49.25) | 194 (26.61) | 48.77 | 0.48 | 0.58 | 1.04 [0.93-1.17] | 0.5 | |
rs34794968 | Controls (n = 3858) | 669 (17.34) | 1842 (47.74) | 1347 (34.91) | 41.21 | ||||
SSc (n = 2060) | 348 (16.89) | 978 (47.48) | 734 (35.63) | 40.63 | 0.73 | 0.73 | 0.99 [0.91-1.07] | 0.37 | |
lcSSc (n = 1422) | 234 (16.46) | 685 (48.17) | 503 (35.37) | 40.54 | 0.74 | 0.95 | 0.99 [0.90-1.08] | 0.71 | |
dcSSc (n = 638) | 114 (17.87) | 293 (45.92) | 231 (36.21) | 40.83 | 0.94 | 0.94 | 1.00 [0.88-1.12] | 0.05 | |
ACA+ (n = 816) | 129 (15.81) | 390 (47.79) | 297 (36.40) | 39.71 | 0.35 | 0.68 | 0.95 [0.85-1.06] | 0.6 | |
ATA+ (n = 518) | 100 (19.31) | 249 (48.07) | 169 (32.63) | 43.34 | 0.28 | 0.28 | 1.08 [0.94-1.23] | 0.38 | |
Fib+ (n = 755) | 122 (16.16) | 362 (47.95) | 271 (35.89) | 40.13 | 0.58 | 0.58 | 0.97 [0.87-1.09] | 0.44 | |
rs727088 | Controls (n = 3815) | 917 (24.04) | 1869 (48.99) | 1029 (26.97) | 48.53 | ||||
SSc (n = 2042) | 489 (23.95) | 1014 (49.66) | 539 (26.40) | 48.78 | 0.59 | 0.73 | 1.02 [0.95-1.10] | 0.86 | |
lcSSc (n = 1409) | 336 (23.85) | 702 (49.82) | 371 (26.33) | 48.76 | 0.63 | 0.95 | 1.02 [0.94-1.11] | 0.66 | |
dcSSc (n = 633) | 153 (24.17) | 312 (49.29) | 168 (26.54) | 48.82 | 0.71 | 0.94 | 1.02 [0.91-1.15] | 0.26 | |
ACA+ (n = 814) | 178 (21.87) | 414 (50.86) | 222 (27.27) | 47.3 | 0.54 | 0.68 | 0.97 [0.87-1.08] | 0.56 | |
ATA+ (n = 514) | 138 (26.85) | 250 (48.64) | 126 (24.51) | 51.17 | 0.14 | 0.28 | 1.10 [0.97-1.26] | 0.61 | |
Fib+ (n = 739) | 185 (25.03) | 363 (49.12) | 191 (25.85) | 49.59 | 0.4 | 0.58 | 1.05 [0.94-1.17] | 0.86 |