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Table 2 Association of four-marker rs9358890-rs3799344-rs1183201-rs12664474 haplotypes with gout

From: The renal urate transporter SLC17A1 locus: confirmation of association with gout

  Frequency   
Haplotypea Case Control OR (95% CI) P value
Caucasian     
   A-T-A-A 270 (0.339) 1044 (0.428) 0.66 (0.56 to 0.78) 1.5 × 10-6
   A-C-T-A 327 (0.410) 876 (0.360) 1.22 (1.03 to 1.44) 0.014
   A-C-T-G 121 (0.152) 284 (0.117) 1.34 (1.06 to 1.69) 0.015
   G-C-T-G 47 (0.059) 104 (0.043) 1.39 (0.98 to 1.98) 0.067
EP/N     
   A-T-A-A 107 (0.239) 101 (0.274) 0.84 (0.61 to 1.15) 0.27
   A-C-T-A 160 (0.356) 109 (0.297) 1.33 (0.99 to 1.78) 0.06
   G-C-T-G 161 (0.360) 140 (0.380) 0.93 (0.70 to 1.23) 0.60
EP/Z     
   A-T-A-A 32 (0.372) 120 (0.414) 0.84 (0.51 to 1.38) 0.49
   A-C-T-A 32 (0.372) 111 (0.384) 0.95 (0.58 to 1.56) 0.84
   G-C-T-G 9 (0.105) 26 (0.090) 1.19 (0.53 to 2.64) 0.68
   A-C-T-G 10 (0.116) 22 (0.075) 1.63 (0.74 to 3.59) 0.23
WP     
   A-C-T-A 171 (0.357) 96 (0.343) 1.07 (0.78 to 1.45) 0.70
   A-T-A-A 116 (0.241) 89 (0.318) 0.68 (0.49 to 0.94) 0.021
   G-C-T-G 171 (0.356) 77 (0.275) 1.46 (1.06 to 2.02) 0.021
   A-C-T-G 12 (0.025) 12 (0.043) 0.57 (0.25 to 1.29) 0.17
EP/WP     
   A-T-A-A 5 (0.167) 16 (0.400) 0.30 (0.10 to 0.95) 0.035
   A-C-T-A 15 (0.500) 13 (0.324) 2.08 (0.78 to 5.50) 0.14
   G-C-T-G 6 (0.200) 11 (0.275) 0.66 (0.21 to 2.05) 0.47
  1. CI, confidence interval; EP, Eastern Polynesian; OR, odds ratio; WP, Western Polynesian. aHaplotypes are listed in descending order of control frequency; those with frequency < 0.03 were excluded.