Table 2 Association of four-marker rs9358890-rs3799344-rs1183201-rs12664474 haplotypes with gout
From: The renal urate transporter SLC17A1 locus: confirmation of association with gout
Frequency | ||||
|---|---|---|---|---|
Haplotypea | Case | Control | OR (95% CI) | P value |
Caucasian | ||||
A-T-A-A | 270 (0.339) | 1044 (0.428) | 0.66 (0.56 to 0.78) | 1.5 × 10-6 |
A-C-T-A | 327 (0.410) | 876 (0.360) | 1.22 (1.03 to 1.44) | 0.014 |
A-C-T-G | 121 (0.152) | 284 (0.117) | 1.34 (1.06 to 1.69) | 0.015 |
G-C-T-G | 47 (0.059) | 104 (0.043) | 1.39 (0.98 to 1.98) | 0.067 |
EP/N | ||||
A-T-A-A | 107 (0.239) | 101 (0.274) | 0.84 (0.61 to 1.15) | 0.27 |
A-C-T-A | 160 (0.356) | 109 (0.297) | 1.33 (0.99 to 1.78) | 0.06 |
G-C-T-G | 161 (0.360) | 140 (0.380) | 0.93 (0.70 to 1.23) | 0.60 |
EP/Z | ||||
A-T-A-A | 32 (0.372) | 120 (0.414) | 0.84 (0.51 to 1.38) | 0.49 |
A-C-T-A | 32 (0.372) | 111 (0.384) | 0.95 (0.58 to 1.56) | 0.84 |
G-C-T-G | 9 (0.105) | 26 (0.090) | 1.19 (0.53 to 2.64) | 0.68 |
A-C-T-G | 10 (0.116) | 22 (0.075) | 1.63 (0.74 to 3.59) | 0.23 |
WP | ||||
A-C-T-A | 171 (0.357) | 96 (0.343) | 1.07 (0.78 to 1.45) | 0.70 |
A-T-A-A | 116 (0.241) | 89 (0.318) | 0.68 (0.49 to 0.94) | 0.021 |
G-C-T-G | 171 (0.356) | 77 (0.275) | 1.46 (1.06 to 2.02) | 0.021 |
A-C-T-G | 12 (0.025) | 12 (0.043) | 0.57 (0.25 to 1.29) | 0.17 |
EP/WP | ||||
A-T-A-A | 5 (0.167) | 16 (0.400) | 0.30 (0.10 to 0.95) | 0.035 |
A-C-T-A | 15 (0.500) | 13 (0.324) | 2.08 (0.78 to 5.50) | 0.14 |
G-C-T-G | 6 (0.200) | 11 (0.275) | 0.66 (0.21 to 2.05) | 0.47 |