| |
Mantel-Haenszel analysis
| |
|---|
|
SNP (locus)
|
OR (95% CI)
|
P value
|
Reference
|
|---|
|
rs1143679 (ITGAM)
|
1.70 (1.50 to 1.93)
|
5.16 × 10-17
|
[24]
|
|
rs7574865 (STAT4)
|
1.52 (1.36 to 1.70)
|
6.11 × 10-14
|
[24]
|
|
rs13277113 (C8orf13-BLK)
|
1.34 (1.20 to 1.50)
|
1.33 × 10-7
|
[24]
|
|
rs2304256 (TYK2)
|
1.32 (1.18 to 1.47)
|
1.17 × 10-6
|
[24]
|
|
rs17435 (MECP2)a
|
1.27 (1.11 to 1.45)
|
5.57 × 10-4
|
[24]
|
|
rs10798269 (1q25.1)
|
1.25 (1.11 to 1.39)
|
6.12 × 10-5
|
[24]
|
|
rs17266594 (BANK1)
|
1.23 (1.10 to 1.37)
|
1.92 × 10-4
|
[24]
|
|
rs4963128 (KIAA1542)
|
1.19 (1.08 to 1.32)
|
1.31 × 10-3
|
[24]
|
|
rs6445975 (PXK)
|
1.15 (1.03 to 1.27)
|
0.02
|
[24]
|
|
rs3131379 (MSH5)
|
2.25 (1.89 to 2.68)
|
6.41 × 10-20
|
-
|
|
rs2187668 (HLA-DQA1)
|
2.17 (1.88 to 2.51)
|
1.09 × 10-25
|
-
|
|
rs10488631 (IRF5)
|
2.00 (1.73 to 2.32)
|
8.38 × 10-21
|
[25]
|
|
rs2230926 (TNFAIP3)
|
1.99 (1.60 to 2.47)
|
2.54 × 10-10
|
-
|
|
rs729302 (IRF5)
|
1.35 (1.20 to 1.49)
|
1.70 × 10-7
|
[25]
|
|
rs2476601 (PTPN22)
|
1.34 (1.13 to 1.60)
|
9.15 × 10-4
|
-
|
|
rs5754217 (UBE2L3)
|
1.26 (1.13 to 1.42)
|
7.30 × 10-5
|
-
|
|
rs2205960 (TNFSF4)
|
1.25 (1.11 to 1.40)
|
1.32 × 10-4
|
-
|
|
rs6920220 (TNFAIP3)
|
1.21 (1.07 to 1.37)
|
2.25 × 10-3
|
-
|
|
rs844644 (TNFSF4)
|
1.19 (1.08 to 1.32)
|
7.22 × 10-4
|
-
|
|
rs1801274 (FCGR2A)
|
1.18 (1.07 to 1.30)
|
1.27 × 10-3
|
-
|
|
rs573775 (ATG5)
|
1.17 (1.05 to 1.31)
|
4.35 × 10-3
|
-
|
|
rs10156091 (ICA1)
|
1.09 (0.93 to 1.28)
|
0.3
|
-
|
|
rs4240671 (XKR6)
|
1.09 (0.98 to 1.19)
|
0.1
|
-
|
|
rs2667978 (LYN)
|
1.06 (0.94 to 1.19)
|
0.3
|
-
|
|
rs6922466 (PERP)
|
1.02 (0.91 to 1.14)
|
0.8
|
-
|
- The first nine SNPs were analysed in the first phase of the study and the remaining 16 in the second. Results of Mantel-Haenszel analysis are shown. All odds ratios (ORs) are expressed for the risk allele. Analyses of some of the SNPs in these samples have already been reported [24, 25]. CI, confidence interval. aAnalysis performed only in women because the locus is in the X chromosome.
