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Table 2 Association results of the 25 systemic lupus erythematosus SNPs

From: Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study

  Mantel-Haenszel analysis  
SNP (locus) OR (95% CI) P value Reference
rs1143679 (ITGAM) 1.70 (1.50 to 1.93) 5.16 × 10-17 [24]
rs7574865 (STAT4) 1.52 (1.36 to 1.70) 6.11 × 10-14 [24]
rs13277113 (C8orf13-BLK) 1.34 (1.20 to 1.50) 1.33 × 10-7 [24]
rs2304256 (TYK2) 1.32 (1.18 to 1.47) 1.17 × 10-6 [24]
rs17435 (MECP2)a 1.27 (1.11 to 1.45) 5.57 × 10-4 [24]
rs10798269 (1q25.1) 1.25 (1.11 to 1.39) 6.12 × 10-5 [24]
rs17266594 (BANK1) 1.23 (1.10 to 1.37) 1.92 × 10-4 [24]
rs4963128 (KIAA1542) 1.19 (1.08 to 1.32) 1.31 × 10-3 [24]
rs6445975 (PXK) 1.15 (1.03 to 1.27) 0.02 [24]
rs3131379 (MSH5) 2.25 (1.89 to 2.68) 6.41 × 10-20 -
rs2187668 (HLA-DQA1) 2.17 (1.88 to 2.51) 1.09 × 10-25 -
rs10488631 (IRF5) 2.00 (1.73 to 2.32) 8.38 × 10-21 [25]
rs2230926 (TNFAIP3) 1.99 (1.60 to 2.47) 2.54 × 10-10 -
rs729302 (IRF5) 1.35 (1.20 to 1.49) 1.70 × 10-7 [25]
rs2476601 (PTPN22) 1.34 (1.13 to 1.60) 9.15 × 10-4 -
rs5754217 (UBE2L3) 1.26 (1.13 to 1.42) 7.30 × 10-5 -
rs2205960 (TNFSF4) 1.25 (1.11 to 1.40) 1.32 × 10-4 -
rs6920220 (TNFAIP3) 1.21 (1.07 to 1.37) 2.25 × 10-3 -
rs844644 (TNFSF4) 1.19 (1.08 to 1.32) 7.22 × 10-4 -
rs1801274 (FCGR2A) 1.18 (1.07 to 1.30) 1.27 × 10-3 -
rs573775 (ATG5) 1.17 (1.05 to 1.31) 4.35 × 10-3 -
rs10156091 (ICA1) 1.09 (0.93 to 1.28) 0.3 -
rs4240671 (XKR6) 1.09 (0.98 to 1.19) 0.1 -
rs2667978 (LYN) 1.06 (0.94 to 1.19) 0.3 -
rs6922466 (PERP) 1.02 (0.91 to 1.14) 0.8 -
  1. The first nine SNPs were analysed in the first phase of the study and the remaining 16 in the second. Results of Mantel-Haenszel analysis are shown. All odds ratios (ORs) are expressed for the risk allele. Analyses of some of the SNPs in these samples have already been reported [24, 25]. CI, confidence interval. aAnalysis performed only in women because the locus is in the X chromosome.