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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model

Figure 3

Effect of interleukin-6 (IL-6) on methotrexate (MTX)-induced anti-proliferative effect. Synoviocytes from arthritic mice were cultured for 24 h with methotrexate (0, 10, 100, 1,000 nM) with medium alone or in the presence of IL-6 (100 ng/mL) + soluble IL-6 receptor (sIL-6R) (100 ng/mL). After culturing, cell proliferation was measured by uptake of bromodeoxyuridine. Statistical significance was analyzed by the unpaired t-test (*P < 0.05). Each column and vertical line indicates the mean and standard deviation of quadruplicate cultures.

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