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Table 2 Clinical and laboratory associations of CD61-positive microthrombi, CD68-positive macrophage infiltration, and C4d deposition

From: Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis

   CD61 microthrombi CD68+ infiltration C4d deposition
   + - Glomerular Extraglomerular Glomerular Extraglomerular
SLEDAI   20.5 ± 6.9 20.3 ± 6.6 r = 0.5a r = 0.3a r = -0.1 r = 0.4a
aPL + 69% 33% 1.9 ± 1.9 1 ± 1.3 2.6 ± 2.9 0.9 ± 1.4
  - 31% 67% 2.1 ± 3.1 0.4 ± 0.6 2.9 ± 4.7 1 ± 1.2
anti-dsDNA + 91% 74% 2.8 ± 3.2a 0.8 ± 1 2.4 ± 2.9 1.2 ± 1.4a
  - 9% 26% 0.6 ± 0.7 0.5 ± 0.8 3.8 ± 6 0.5 ± 0.5
Low complement + 94% 87% 2.6 ± 3.1a 0.7 ± 1 2.4 ± 2.9 1.1 ± 1.4
  - 6% 13% 0.5 ± 0.5 0.9 ± 0.9 5.4 ± 8 0.8 ± 0.5
24-hour proteinuria (g)   3.2 ± 3.1 3.6 ± 3.6 r = 0.4a r = 0.4a r = 0.1 r = 0.3a
Hematuria + 88% 84% 2.7 ± 3.2a 0.8 ± 0.9 2.7 ± 3.9 1.1 ± 1.4
  - 12% 16% 0.6 ± 0.7 0.6 ± 1.4 2.9 ± 2.9 0.5 ± 0.6
Leukocyturia + 76.50% 84% 2.7 ± 3.2a 0.7 ± 0.9 2.7 ± 3.6 1.1 ± 1.4
  - 23.50% 16% 1.3 ± 1.5 0.7 ± 1.2 2.8 ± 4.5 0.8 ± 1
Cellular casts + 62% 68% 3.1 ± 3.5a 0.8 ± 0.8 3.1 ± 4.2 1.1 ± 1.2
  - 38% 32% 1.1 ± 1.3 0.7 ± 1.3 2.1 ± 2.7 0.9 ± 1.6
Creatinine clearance   97.9 ± 50.2 84.3 ± 35.6 r = -0.01 r = -0.2 r = 0.1 r = - 0.1
Response to treatment + 81% 95% 3.1 ± 3.5 0.8 ± 0.9 2.9 ± 4.2 1.2 ± 1.5
  - 19% 5% 2.2 ± 1.4 1.3 ± 1.7 1.9 ± 1.5 0.9 ± 0.4
Mean time to response   25.1 ± 27.9 8.8 ± 10.8 r = -0.15 r = -0.26 r = -0.17 r = -0.05
LN relapse + 33% 45% 2.8 ± 3.3 0.6 ± 0.7 1.9 ± 2.9 1.1 ± 1.1
  - 67% 55% 3.4 ± 4.4 0.7 ± 0.8 2.9 ± 3.5 1.4 ± 1.9
Renal failure at 1 year + 17.40% 15% 3.2 ± 3.6 0.8 ± 0.9 2.9 ± 4.2 1.3 ± 1.6
  - 82.60% 85% 1.9 ± 2.1 1.5 ± 1.6 1.3 ± 1.7 1.2 ± 0.7
Renal failure at last visit + 20.80% 30% 3.3 ± 3.7 0.9 ± 1 3 ± 4.4 1.3 ± 1.6
  - 79.20% 70% 2.1 ± 1.9 1 ± 1.4 1.5 ± 1.7 1 ± 0.7
  1. aP < 0.05.