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Table 2 Clinical and laboratory associations of CD61-positive microthrombi, CD68-positive macrophage infiltration, and C4d deposition

From: Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis

  

CD61 microthrombi

CD68+ infiltration

C4d deposition

  

+

-

Glomerular

Extraglomerular

Glomerular

Extraglomerular

SLEDAI

 

20.5 ± 6.9

20.3 ± 6.6

r = 0.5a

r = 0.3a

r = -0.1

r = 0.4a

aPL

+

69%

33%

1.9 ± 1.9

1 ± 1.3

2.6 ± 2.9

0.9 ± 1.4

 

-

31%

67%

2.1 ± 3.1

0.4 ± 0.6

2.9 ± 4.7

1 ± 1.2

anti-dsDNA

+

91%

74%

2.8 ± 3.2a

0.8 ± 1

2.4 ± 2.9

1.2 ± 1.4a

 

-

9%

26%

0.6 ± 0.7

0.5 ± 0.8

3.8 ± 6

0.5 ± 0.5

Low complement

+

94%

87%

2.6 ± 3.1a

0.7 ± 1

2.4 ± 2.9

1.1 ± 1.4

 

-

6%

13%

0.5 ± 0.5

0.9 ± 0.9

5.4 ± 8

0.8 ± 0.5

24-hour proteinuria (g)

 

3.2 ± 3.1

3.6 ± 3.6

r = 0.4a

r = 0.4a

r = 0.1

r = 0.3a

Hematuria

+

88%

84%

2.7 ± 3.2a

0.8 ± 0.9

2.7 ± 3.9

1.1 ± 1.4

 

-

12%

16%

0.6 ± 0.7

0.6 ± 1.4

2.9 ± 2.9

0.5 ± 0.6

Leukocyturia

+

76.50%

84%

2.7 ± 3.2a

0.7 ± 0.9

2.7 ± 3.6

1.1 ± 1.4

 

-

23.50%

16%

1.3 ± 1.5

0.7 ± 1.2

2.8 ± 4.5

0.8 ± 1

Cellular casts

+

62%

68%

3.1 ± 3.5a

0.8 ± 0.8

3.1 ± 4.2

1.1 ± 1.2

 

-

38%

32%

1.1 ± 1.3

0.7 ± 1.3

2.1 ± 2.7

0.9 ± 1.6

Creatinine clearance

 

97.9 ± 50.2

84.3 ± 35.6

r = -0.01

r = -0.2

r = 0.1

r = - 0.1

Response to treatment

+

81%

95%

3.1 ± 3.5

0.8 ± 0.9

2.9 ± 4.2

1.2 ± 1.5

 

-

19%

5%

2.2 ± 1.4

1.3 ± 1.7

1.9 ± 1.5

0.9 ± 0.4

Mean time to response

 

25.1 ± 27.9

8.8 ± 10.8

r = -0.15

r = -0.26

r = -0.17

r = -0.05

LN relapse

+

33%

45%

2.8 ± 3.3

0.6 ± 0.7

1.9 ± 2.9

1.1 ± 1.1

 

-

67%

55%

3.4 ± 4.4

0.7 ± 0.8

2.9 ± 3.5

1.4 ± 1.9

Renal failure at 1 year

+

17.40%

15%

3.2 ± 3.6

0.8 ± 0.9

2.9 ± 4.2

1.3 ± 1.6

 

-

82.60%

85%

1.9 ± 2.1

1.5 ± 1.6

1.3 ± 1.7

1.2 ± 0.7

Renal failure at last visit

+

20.80%

30%

3.3 ± 3.7

0.9 ± 1

3 ± 4.4

1.3 ± 1.6

 

-

79.20%

70%

2.1 ± 1.9

1 ± 1.4

1.5 ± 1.7

1 ± 0.7

  1. aP < 0.05.