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Table 2 Effect of anti-TNFα treatment on clinical and metabolic profile in rheumatoid arthritis RA patients with low and high baseline insulin resistance*

From: Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance

  Insulin resistance    
  Low (n= 31) Pvalue† High (n= 30) Pvalue
DAS28 -0.52 (-1.20, 0.16) 0.127 -0.57 (-1.01, -0.13) 0.013
HAQ -0.23 (-0.42, -0.05) 0.018 -0.26 (-0.45, -0.06) 0.012
ESR -3.04 (-15.3, 9.20) 0.611 -1.04 (-7.91, 5.84) 0.760
C-reactive protein # -0.69 (-1.91, 0.53) 0.147 -0.83 (-1.72, 0.05) 0.007
TC -5.92 (-20.0, 8.21) 0.395 8.63 (-6.53, 23.8) 0.253
Triglycerides 12.3 (-16.7, 41.3) 0.390 -24.5 (-47.7, -1.31) 0.039
HDL-C 0.75 (-3.25, 4.75) 0.701 4.21 (0.65, 7.78) 0.022
LDL-C -9.78 (-20.2, 0.64) 0.065 9.15 (-3.94, 22.2) 0.163
TC/HDL-C -0.08 (-0.35, 0.18) 0.511 -0.12 (-0.44, 0.19) 0.421
LDL-C/HDL-C -0.14 (-0.31, 0.03) 0.110 0.01 (-0.25, 0.27) 0.929
Lpa # -4.38 (-9.31, 0.55) 0.147 0.25 (-7.72, 8.22) 0.200
apoA -6.12 (-17.3, 5.03) 0.262 5.64 (-3.94, 15.2) 0.236
apoB -2.99 (-13.0, 6.99) 0.534 2.09 (-4.81, 8.99) 0.537
Homocysteine # -2.66 (-5.88, 0.57) 0.122 2.53 (-0.35, 5.41) 0.039
FBG 1.08 (-1.02, 1.18) 0.117 -19.7 (-34.8, -4.61) 0.016
HOMA-IR # 1.87 (-0.34, 4.09) 0.197 -5.68 (-8.86, -2.50) < 0.001
HOMA-B # -130 (-375, 116) 0.446 -148 (-244, -46) 0.001
QUICKI # -0.01 (-0.03, 0.01) 0.264 0.07 (0.04, 0.09) < 0.001
Insulin # 5.80 (-1.12, 12.7) 0.301 -21.7 (-33.8, -9.62) < 0.001
  1. Values are the mean (95% confidence interval)
  2. * The median Homeostasis Model Assessment for insulin resistance (HOMA-IR) value at baseline was used to assign patients into low (HOMA-IR ≤ 3.18, n = 31) or high (HOMA-IR > 3.18, n = 30) insulin resistance group
  3. † Paired t-test for comparison of values between baseline and after 12 weeks of anti-TNF treatment
  4. # Statistical comparisons were performed using log transformed values
  5. DAS28: disease activity score of 28 joints; HAQ: health assessment questionnaire; ESR: erythrocyte sedimentation rate; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; Lpa: lipoprotein a; apo: apolipoprotein; FBG: fasting blood glucose; QUICKI: Quantitative Insulin Sensitivity Check Index.