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Figure 4 | Arthritis Research & Therapy

Figure 4

From: B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin

Figure 4

Phosphorylated platelet-derived growth factor receptor expression in the rituximab treated systemic sclerosis patients. Substantial reduction of collagen accumulation following rituximab (RTX) treatment (B) compared with baseline (A) in Patient 2 (Masson's trichrome ×100). Immunohistochemical staining for phosphorylated platelet-derived growth factor receptor (PDGFR)α and PDGFRβ in the same patient prior to ((C) and (E), respectively) and following ((D) and (F), respectively) RTX treatment, where a significant decrease in phospho-PDGFR staining can be seen (streptavidin peroxidase ×100). Red arrow in the boxed area points to a spindle-like cell (among others) expressing phosphorylated PDGFRα and PDGFRβ.

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Arthritis Research & Therapy

ISSN: 1478-6362

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