Figure 1
Schematic representation of experimental models and evaluation of juxta-articular bone loss. (A) Antigen-induced arthritis (AIA) was induced in seven rabbits by immunization and following weekly intra-articular knee injections of ovalbumin (OVA). Surgical osteoarthritis (OA) was induced in the knees of three rabbits by partial medial meniscectomy (PMM) and transection of the anterior cruciate ligament (ACLT). (B) Representative antero-posterior radiography of the knees in each group of rabbits. (C) Densitometric analysis of subchondral bone mineral density (BMD, g/cm2) in each group of rabbits. The results are expressed as mean ± standard deviation (SD) for healthy rabbits (H), and rabbits with osteoarthritis (OA) and chronic antigen-induced arthritis (AIA).