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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

Figure 2

Effect of HA injection on macroscopic pathology in the TTR model. Knee joints were carefully opened, and after rinsing with PBS, India ink was applied to all surfaces with a paint brush and rinsed again. Menisci and articular surfaces were photographed under a Nikon dissecting microscope (SMZ1000, X6) and images processed with Spot Basic, Diagnostic Instruments, Inc (Sterling Heights, MI, USA). Typical images of meniscus and cartilage surfaces from naïve joints and joints from each of the three experimental groups at Day 19 (TTR, TTR+HA and TTR+SA) are shown. Black arrow heads indicate cartilage erosion and black stars indicate fibrotic overgrowth.

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Arthritis Research & Therapy

ISSN: 1478-6362

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