Arthritis Research & Therapy

Table 6 Summary of tissue changes in the TTR model illustratesthe therapeutic effects of HA injection.

From: Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

	TTR Relative to Naive	TTR+HA Relative to TTR	TTR+Saline Relative to TTR
CARTILAGE/SUBCHONDRAL BONE
Erosion	+++¹	--¹	Unchanged
Chondrogenic Genes	Unchanged	+++	Unchanged
Fibrogenic Genes	+++	---	Unchanged
MMP Genes	+++	---	+
SYNOVIUM/MENISCUS
Perimeniscal Synovitis	+++	--	Unchanged
Chondrogenic Genes	+++	---	Unchanged
Fibrogenic Genes	+++	---	Unchanged
MMP Genes	+++	---	+

¹+/- = 2- to 4-fold Increase/decrease; ++/-- = 2- to 4-fold Increase/decrease; +++/--- = 5- to 10-fold increase

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ISSN: 1478-6362

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