Table 5 Clinical outcomes by history of use of oral contraceptives
From: Early menopause and severity of rheumatoid arthritis in women older than 45 years
Never used (n= 67) a | 1-5 years of use (n= 17) a | > 5 years of use (n= 43) a | |
|---|---|---|---|
Mean age at diagnosis; years (SD) | 66.2 (7.82) | 58.8 (8.19) | 60.1 (7.17) |
Mean follow-up time; years (SD) | 10.4 (3.3) | 9.9 (3.1) | 10.0 (3.8) |
> 3 DMARDs used (%) | 11/67 (16.4) | 4/17 (23.5) | 14/42 (33.3) |
DMARDs in combination (%) | 26/67 (38.8) | 8/17 (47.1) | 20/42 (47.6) |
Biological treatment ever (%) | 14/67 (20.9) | 4/17 (23.5) | 19/42 (45.2) |
Documented radiographic erosions (ever) (%) | 37/62 (59.7) | 10/17 (58.8) | 20/40 (50.0) |
RF positive (%) | 46/66 (69.7) | 10/16 (62.5) | 34/43 (79.1) |
Mean HAQ at diagnosis (CI)b | 0.75 (0.53-0.97) (n = 34) | 0.93 (0.42-1.43) (n = 6) | 1.06 (0.81-1.30) (n = 27) |
Mean HAQ 1 year after diagnosis (CI)b | 0.83 (0.61-1.05) (n = 39) | 0.64 (0.20-1.09) (n = 9) | 0.81 (0.56-1.06) (n = 29) |
Mean HAQ 5 years after diagnosis (CI)b | 0.93 (0.75-1.11) (n = 47) | 0.80 (0.46-1.15) (n = 13) | 0.86 (0.62-1.10) (n = 26) |
Mean HAQ 10 years after diagnosis (CI)b | 0.79 (0.59-1.00) (n = 33) | 1.20 (0.77-1.63) (n = 7) | 1.00 (0.75-1.26) (n = 21) |
Cluster distribution (P = 0.56) | |||
Severe RA (%) | 12/47 (25.5) | 3/12 (25.0) | 11/25 (44.0) |
Mild/moderate seropos RA (%) | 21/47 (44.7) | 5/12 (41.7) | 9/25 (36.0) |
Mild/moderate seroneg RA (%) | 14/47 (29.8) | 4/12 (33.3) | 5/25 (20.0) |