T-cell activation without proliferation in juvenile idiopathic arthritis

Table 3 Synovial fluid T-cell expression of differentiation and activation markers in disease subgroups of patients with juvenile idiopathic arthritis

SF T cells	Oligo	Poly	JPsA	B27^-	B27⁺	ANA^-	ANA⁺	APR hi	APR lo	Drugs⁺	Drugs^-
CD69	10.1	15.8	13.4	14.3	11.8	13.1	15.8	14.4	8.9	14.6	14.3
CD25	3.9	3.9	4.4	4.2	3.6	4.2	3.9	4.0	4.2	4.2	4.0
CD71	3.5	3.4	4.5	3.7	3.5	3.7	3.6	3.8	3.2^*	3.7	3.7
HLA-DR	13.1	33.5	30.2	20.5	11.8	18.9	47.4	16.0	19.6	19.2	30.2
CD45RO	74.6	78.8	81.1	77.8	80.1	76.4	78.9	78.9	77.8	77.3	79.0
CD45RB	78.4	88.8	92.2	89.4	106.7	88.3	89.8	85.1	89.8	92.2	69.9

All values represented as median fluorescence intensity (MFI) except CD45RO, which is represented as median % positive. Patients were grouped according to disease subgroup (oligoarthritis, polyarthritis or psoriatic arthritis), and expression or absence of HLA-B27, ANA, a high or low acute-phase response (high: erythrocyte sedimentation rate >20 or C-reactive protein >5), and whether they had received intra-articular triamcinolone hexacetonide earlier in their disease process (drugs⁺ versus drugs^-). There was a statistically significant difference between those groups of patients with a high or low APR (^*P < 0.05). ANA = antinuclear antibodies; APR = acute-phase response; hi = high; lo = low; JPsA = juvenile psoriatic arthritis; Oligo = oligoarthritis; Poly = polyarthritis.

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