Decreased IL-20 expression in PsA skin lesions after alefacept treatment. (A) Representative immunohistochemical staining of IL-20 expression in the lesional skin of a PsA patient. (B) Quantification of IL-20 expression in PsA lesional skin. Results are shown as median of semiquantitative score (SQ) of six patients with PsA. (C) IL-20 expression in PsA lesional skin is correlated with disease activity (PASI). All time points are depicted (each dot represents one patient per time point). *Statistical significance, P = 0.04. Original magnification, ×200. CRP, C-reactive protein; DAS28, disease activity score; ESR, erythrocyte sedimentation rate; SJC, swollen-joint count; TJC, tender-joint count; VAS, visual analogue scale (100 mm).