Table 3 Baseline cytokine expression of nasal epithelial cells (pg/ml)
From: Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis
Normal control (NC) | Granulomatosis with polyangiitis (GPA) | NC vs. GPA | |||
|---|---|---|---|---|---|
median | range | median | range | P-value | |
IL- 1α | 71.74 | <1.51 to 319.24 | 92.38 | 7.90 to 477.11 | 0.322 |
IL-1β | <2.67 | <2.67 to 8.67 | 2.70 | <2.67 to 12.74 | 0.224 |
IL-2 | <1.42 | <1.42 to 6.46 | 3.60 | <1.42 to 6.00 | 0.070 |
IL-4 | <0.32 | <0.32 to 0.80 | <0.32 | <0.32 to 0.72 | 0.283 |
IL-5 | below detection limit (<2.51) | ||||
IL-6 | 26.22 | 2.81 to 788.29 | 29.61 | 3.70 to 139.47 | 0.607 |
IL-7 | below detection limit (<2.43) | ||||
IL-8 | 1388.14 | <1.77 to 5188.14 | 319.16 | <1.77 to 3708.72 | 0.009 |
IL-10 | below detection limit (<1.78) | ||||
IL-12 | <2.55 | <2.55 to 3.75 | <2.55 | <2.55 to 4.03 | 0.283 |
IL-13 | below detection limit (<2.68) | ||||
IL-17 | 2.77 | <1.87 to 6.41 | 3.54 | <1.87 to 6.01 | 0.101 |
G-CSF | 19.60 | <1.31 to 204.41 | 61.30 | 1.53 to 663.58 | 0.050 |
GM-CSF | 10.50 | <0.74 to 28.70 | 12.50 | 7.74 to 21.56 | 0.084 |
IFN-γ | 4.61 | <1.61 to 21.41 | 5.92 | 2.27 to 18.18 | 0.089 |
MCP-1 | 3.66 | <1.81 to 8.21 | 4.12 | <1.81 to 7.90 | 0.667 |
MIP-1β | <1.41 | <1.41 to 2.37 | 1.43 | <1.41 to 2.79 | 0.141 |
TNF-α | <6.42 | <6.42 to 13.46 | <6.42 | <6.42 to 11.00 | 0.296 |
TNF-β | 9.44 | <2.14 to 24.46 | 14.20 | 3.35 to 23.40 | 0.054 |