Figure 4

Soleus muscle gene transcripts indicative of fast or slow myofiber type. The cell color codes in the heat map indicate relative transcript amounts in the soleus muscles of eight control rats and eight rats treated with zidovudine. Fast myofiber transcripts: Mylpf, myosin light chain, phosphorylatable (skeletal fast); Tnnt3, troponin T type 3 (skeletal, fast); troponin C type 2 (skeletal fast); Myh2, myosin, heavy polypeptide 2 (skeletal muscle, adult); Tnni2, troponin I type 2 (skeletal, fast); Myh1, myosin, heavy polypeptide 1 (skeletal muscle, adult); Actn3, actinin α3; Myh4, myosin, heavy-chain 4, (skeletal muscle); Mybpc2, myosin-binding protein C, fast-type; Pvalb, parvalbumin. Slow myofiber transcripts: Cryab, crystallin, αB; Myl3, myosin, light-chain 3, alkali; (ventricular, skeletal, slow); Myh7, myosin, heavy-chain 7, cardiac muscle, β; Actn2, actinin α2; Atp2a2, ATPase, Ca²⁺ transporting, cardiac muscle, slow twitch 2; Ankrd2, ankyrin repeat domain 23; Tnni1, troponin I type 1 (skeletal, slow); Tnnc1, troponin C type 1 (slow); Myl2, myosin, light polypeptide 2, regulatory, cardiac, slow; Tnnt1, troponin T type 1 (skeletal, slow); Pdlim1, PDZ and LIM domain 1; RGD1309537, similar to myosin regulatory light-chain 2-A, smooth muscle isoform (myosin RLC-A); Myh7b, myosin, heavy-chain 7B, cardiac muscle, β; RGD1560334, similar to myosin light-chain 1 slow α.