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Table 4 Association of main baseline characteristics of patients with early RA and rapid radiographic progression (RRP) of rheumatoid arthritis (univariate analysis).

From: Matrix to predict rapid radiographic progression of early rheumatoid arthritis patients from the community treated with methotrexate or leflunomide: results from the ESPOIR cohort

  With RRP
(number = 41)
Without RRP
(number = 329)
P valuea
Age, years 49.8 ± 12 (52.7) 49.3 ± 11.5 (7) 0.6
Sex 31 (75.6%) 240 (73%) 0.85
Disease duration, weeks 18.6 ± 8.4 (18.6) 14.7 ± 8.1 (13) 0.007
SJC in 28 joints 8.6 ± 6.1 (8) 7.8 ± 5.3 (7) 0.5
   < 14 31 (75.6) 285 (86.6)  
   14 to 20 6 (14.6) 32 (9.7) 0.08
   ≥ 20 4 (12.2) 12 (3.6)  
TJC in 28 joints 8.3 ± 6.3 (7) 8.7 ± 6.9 (7) 0.97
ESR, mm/1 hr 32.6 ± 21.3 (30) 32.7 ± 25.4 (25) 0.5
CRP, mg/L 26.2 ± 27.9 (14) 24.6 ± 38.7 (11) 0.12
   < 4 4 (9.7) 89 (27.1)  
   4 to 35 25 (61) 168 (51.1) 0.04
   ≥ 35 12 (29.3.8) 72 (21.9)  
Elevated ESR or CRP level 38 (90.3) 289 (87.8) 0.45
DAS28(ESR)-4v 5.3 ± 1.2 (5.4) 5.3 ± 1.2 (5.2) 0.8
RF positivity 29 (70.7) 175 (53.2) 0.04
ACPA positivity 31 (75.6) 154 (46.8) 0.0008
RF or ACPA positivity 32 (78) 190 (57.8) 0.01
HAQ score 0.95 ± 0.6 (1) 1.04 ± 0.7 (1) 0.5
Typical RA erosion 18 (44) 48 (14.6) < 0.0001
Prednisone ≥ 7.5 mg/d 2 (4.9) 35 (10.6) 0.4
   ≥ 5 mg/d 7 (17.7) 91 (27.7) 0.19
Delay before 1st DMARD initiation ≥ 6 months after RA onset 22 (53.7) 147 (44.7) 0.32
Satisfaction of 2010 ACR/EULAR criteria 38 (92.7) 278 (84.5) 0.24
  1. Data are mean ± SD (median) or number (%). RRP-positive status was defined by progression of the vSHS total score ≥ 5 points between baseline and one year (of note, among the 46 patients with RRP, 44 had progression with vSHS erosion score ≥ 5 points and 13 with vSHS narrowing score ≥ 5 points). aStudent t test or Mann-Whitney U test for continuous variables and Fischer exact test for categorical variables, with P < 0.1. ACPA, anti-citrullinated protein antibody; ACR/EULAR, American College of Rheumatology/European League Against Rheumatism; CRP, C-reactive protein; DAS28(ESR)-4v, Disease Activity Score in 28 joints-4 variables, using erythrocyte sedimentation rate; DMARD, disease-modifying anti-rheumatic drugs; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; RF, rheumatoid factor; SJC, swollen joint count; TJC, tender joint count; vSHS, van der Heijde-modified Sharp score.