Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis

Table 2 Significant SNP variants associated with ACPA-positive and ACPA-negative RA in the MyEIRA study population

Ethic group	SNP variant	Risk allele	Ratio counts (case, control)	Frequencies (case, control)	χ ²	Pvalue
ACPA-positive RA
Malay	rs12042956	G	50:562, 103:1819	0.082, 0.054	6.465	0.011
Malay	rs7538876	G	496:122, 1480:478	0.803, 0.756	5.738	0.0166
Malay	rs2526839	C	240:378, 667:1291	0.388, 0.341	4.684	0.0304
Chinese	rs3003444	A	247:83, 262:142	0.748, 0.649	8.539	0.0035
Chinese	rs2977299	G	223:107, 235:169	0.676, 0.582	6.851	0.0089
Chinese	rs3766298	A	223:107, 234:168	0.676, 0.582	6.779	0.0092
Indian	rs113475583	G	481:21, 532:44	0.958, 0.924	5.653	0.0174
Indian	rs72633848	A	483:21, 536:44	0.958, 0.924	5.594	0.018
Indian	rs35903413	G	498:6, 564:16	0.988, 0.972	3.335	0.0678
ACPA-negative RA
Malay	rs16825533	G	67:337, 227:1731	0.166, 0.116	7.654	0.0057
Malay	rs57744451	G	67:339, 234:1724	0.165, 0.120	6.269	0.0123
Malay	rs2240337	G	388:14, 1826:128	0.965, 0.934	5.541	0.0186
Chinese	rs3003444	A	125:43, 262:142	0.744, 0.649	4.949	0.0261
Chinese	rs12037558	A	113:53, 237:167	0.681, 0.587	4.395	0.036
Chinese	rs2977296	G	145:23, 320:84	0.863, 0.792	3.935	0.0473
Indian	rs12042956	A	223:13, 506:64	0.945, 0.888	6.319	0.0119
Indian	rs2977305	A	242:4, 550:26	0.984, 0.955	4.088	0.0432
Indian	rs34324150	G	242:4, 552:26	0.984, 0.955	4.058	0.044

Top three significant SNP variants associated with risk of developing anti-citrullinated protein autoantibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) in three major ethnic groups from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) study population

ISSN: 1478-6362