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Table 2 Significant SNP variants associated with ACPA-positive and ACPA-negative RA in the MyEIRA study population

From: Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis

Ethic group SNP variant Risk allele Ratio counts (case, control) Frequencies (case, control) χ 2 Pvalue
ACPA-positive RA       
   Malay rs12042956 G 50:562, 103:1819 0.082, 0.054 6.465 0.011
   Malay rs7538876 G 496:122, 1480:478 0.803, 0.756 5.738 0.0166
   Malay rs2526839 C 240:378, 667:1291 0.388, 0.341 4.684 0.0304
   Chinese rs3003444 A 247:83, 262:142 0.748, 0.649 8.539 0.0035
   Chinese rs2977299 G 223:107, 235:169 0.676, 0.582 6.851 0.0089
   Chinese rs3766298 A 223:107, 234:168 0.676, 0.582 6.779 0.0092
   Indian rs113475583 G 481:21, 532:44 0.958, 0.924 5.653 0.0174
   Indian rs72633848 A 483:21, 536:44 0.958, 0.924 5.594 0.018
   Indian rs35903413 G 498:6, 564:16 0.988, 0.972 3.335 0.0678
ACPA-negative RA       
   Malay rs16825533 G 67:337, 227:1731 0.166, 0.116 7.654 0.0057
   Malay rs57744451 G 67:339, 234:1724 0.165, 0.120 6.269 0.0123
   Malay rs2240337 G 388:14, 1826:128 0.965, 0.934 5.541 0.0186
   Chinese rs3003444 A 125:43, 262:142 0.744, 0.649 4.949 0.0261
   Chinese rs12037558 A 113:53, 237:167 0.681, 0.587 4.395 0.036
   Chinese rs2977296 G 145:23, 320:84 0.863, 0.792 3.935 0.0473
   Indian rs12042956 A 223:13, 506:64 0.945, 0.888 6.319 0.0119
   Indian rs2977305 A 242:4, 550:26 0.984, 0.955 4.088 0.0432
   Indian rs34324150 G 242:4, 552:26 0.984, 0.955 4.058 0.044
  1. Top three significant SNP variants associated with risk of developing anti-citrullinated protein autoantibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) in three major ethnic groups from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) study population