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Table 3 Haplotype frequencies and meta-analysis of PADI4 polymorphisms in relation to RA in the MyEIRA study

From: Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis

Block Ethnicity Haplotype frequency Ratio counts (case, control) Frequencies (case, control) χ 2 Pvalue OR (95% CI) Meta-analysis P het I2 (%)
ACGG Malay 0.501 510.8:537.2, 984.2:951.8 0.487, 0.508 1.195 0.2744 0.92 (0.79 to 1.07) 0.91 (0.82 to 1.02), Z = 1.62 (P = 0.10) 0.64 0
  Chinese 0.567 288.8:217.2, 224.7:175.3 0.571, 0.562 0.076 0.7835 1.04 (0.80 to 1.35)    
  Indian 0.413 292.7:453.3, 246.1:313.9 0.392, 0.439 2.919 0.0875 0.83 (0.66 to 1.03)    
  Others 0.46 78.8:97.2, 88.6:99.4 0.447, 0.471 0.204 0.6519 0.91 (0.60 to 1.37)    
ATAA Malay 0.055 42.5:1,005.5, 120.7:1,815.3 0.041, 0.062 6.226 0.0126 0.64 (0.45 to 0.92) 0.71 (0.54-0.94), Z = 2.42 (P = 0.02) 0.78 0
  Chinese 0.064 29.0:477.0, 29.0:371.0 0.057, 0.073 0.86 0.3537 0.78 (0.46 to 1.32)    
  Indian 0.015 9.7:736.3, 9.3:550.7 0.013, 0.017 0.293 0.5886 0.83 (0.34 to 2.06)    
  Others 0.039 7.3:168.7, 7.0:181.0 0.042, 0.037 0.046 0.8296 1.07 (0.37 to 3.12)    
ATAG Malay 0.287 333.6:714.4, 522.9:1,413.1 0.318, 0.270 7.736 0.0054 1.26 (1.07 to 1.49) 1.21 (1.08-1.36), Z = 3.20 (P = 0.001) 0.78 0
  Chinese 0.274 140.8:365.2, 107.1:292.9 0.278, 0.268 0.128 0.7202 1.06 (0.79 to 1.42)    
  Indian 0.398 312.4:433.6, 207.6:352.4 0.419, 0.371 3.09 0.0788 1.22 (0.97 to 1.52)    
  Others 0.34 62.5:113.5, 61.4:126.6 0.355, 0.326 0.336 0.562 1.16 (0.75 to 1.79)    
ATGG Malay 0.096 108.7:939.3, 178.8:1,757.2 0.104, 0.092 1.001 0.317 1.14 (0.89 to 1.46) 1.02 (0.77-1.36), Z = 0.14 (P = 0.89) 0.24 29
  Chinese 0.046 23.2:482.8, 18.3:381.7 0.046, 0.046 0.0 0.9908 1.01 (0.54 to 1.90)    
  Indian 0.049 39.1:706.9, 25.3:534.7 0.052, 0.045 0.351 0.5538 1.18 (0.71 to 1.97)    
  Others 0.091 11.0:165.0, 22.0:166.0 0.063, 0.117 3.268 0.0706 0.50 (0.24 to 1.07)    
GTAG Malay 0.041 38.6:1,009.4, 83.8:1,852.2 0.037, 0.043 0.714 0.398 0.85 (0.58 to 1.26) 0.94 (0.72-1.21), Z = 0.49 (P = 0.63) 0.59 0
  Chinese 0.042 20.1:485.9, 17.9:382.1 0.040, 0.045 0.138 0.7099 0.87 (0.46 to 1.67)    
  Indian 0.065 47.9:698.1, 37.1:522.9 0.064, 0.066 0.023 0.8798 0.97 (0.62 to 1.51)    
  Others 0.046 10.4:165.6, 6.4:181.6 0.059, 0.034 1.326 0.2496 1.83 (0.65 to 5.14)    
  1. CI, confidence interval; I2, degree of heterogeneity (%); MyEIRA, Malaysian Epidemiological Investigation of Rheumatoid Arthritis; OR, odds ratio; PADI, peptidylarginine deiminase; Phet, P value for heterogeneity; RA, rheumatoid arthritis.