Figure 1From: Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosisProteinase-3 (PR-3) mRNA is expressed in alveolar epithelial cells in a human lung specimen (arrows). The expression of PR-3 mRNA was detected by nonradioactive in situ hybridization. Double-labeling with CD15 revealed some infiltrating neutrophils (red cells), different from the PR-3 mRNA expressing cells (magnification, 40 × 2.5).Back to article page