Raised circulating tenascin-C in rheumatoid arthritis

Table 2 Circulating levels of tenascin-C (TNC) are raised in a number of inflammatory conditions

Sample	Mean TNC (ng/ml)	Number of samples	P-value (compared to N)	Patients with abnormal TNC, %
Normal healthy subjects (N)	20.7 (95% CI = 33)	19
Rheumatoid arthritis (RA)	118.2	40	< 0.0001	82.5
Systemic lupus erythmatosus (SLE)	77.8	24	< 0.0001	83.3
Sjogren's syndrome (SS)	16.7	24	0.3489	8.3
Idiopathic inflammatory myositis (IIM)	69.8	25	0.0008	64.0
Psoriatic arthritis (PSA)	64.7	6	0.0026	100.0
Ankylosing spondylitis (AS)	53.8	13	0.0006	76.9

Blood was taken from normal healthy controls (N) and patients with RA, SLE, SS, IIM, PSA and AS, and TNC levels were determined in serum by ELISA. The 95% confidence interval (CI) of TNC levels in normal healthy subjects was determined to be 33 ng/ml. The P-value was determined by Student's t-test.

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